Gene

prkg1a

ID
ZDB-GENE-040426-1308
Name
protein kinase cGMP-dependent 1a
Symbol
prkg1a Nomenclature History
Previous Names
  • prkg1
  • zgc:63955 (1)
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have ATP binding activity; cGMP binding activity; and cGMP-dependent protein kinase activity. Predicted to be involved in protein phosphorylation. Human ortholog(s) of this gene implicated in thoracic aortic aneurysm. Is expressed in several structures, including heart; nervous system; neural tube; notochord; and pleuroperitoneal region. Orthologous to human PRKG1 (protein kinase cGMP-dependent 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With prkg1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
thoracic aortic aneurysm Alliance Aortic aneurysm, familial thoracic 8 615436
Associated With prkg1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR018488 Cyclic nucleotide-binding, conserved site
Domain IPR000595 Cyclic nucleotide-binding domain
Domain IPR000719 Protein kinase domain
Domain IPR000961 AGC-kinase, C-terminal
Domain IPR031831 cGMP-dependent protein kinase, N-terminal coiled-coil domain
Domain IPR035014 cGMP-dependent protein kinase, catalytic domain
Family IPR002374 cGMP-dependent kinase
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR014710 RmlC-like jelly roll fold
Homologous_superfamily IPR018490 Cyclic nucleotide-binding domain superfamily
Domain Details Per Protein
Protein Length AGC-kinase, C-terminal cGMP-dependent kinase cGMP-dependent protein kinase, catalytic domain cGMP-dependent protein kinase, N-terminal coiled-coil domain Cyclic nucleotide-binding, conserved site Cyclic nucleotide-binding domain Cyclic nucleotide-binding domain superfamily Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily RmlC-like jelly roll fold Serine/threonine-protein kinase, active site
UniProtKB:Q7T2E5 667
UniProtKB:A0A8M2B3F1 684
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA prkg1a-201 (1) Ensembl 3,095 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations