Gene
prkg1a
- ID
- ZDB-GENE-040426-1308
- Name
- protein kinase cGMP-dependent 1a
- Symbol
- prkg1a Nomenclature History
- Previous Names
-
- prkg1
- zgc:63955 (1)
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity; cGMP binding activity; and cGMP-dependent protein kinase activity. Predicted to be involved in protein phosphorylation. Human ortholog(s) of this gene implicated in thoracic aortic aneurysm. Is expressed in several structures, including heart; nervous system; neural tube; notochord; and pleuroperitoneal region. Orthologous to human PRKG1 (protein kinase cGMP-dependent 1).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63955 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
thoracic aortic aneurysm | Alliance | Aortic aneurysm, familial thoracic 8 | 615436 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
Binding_site | IPR017441 | Protein kinase, ATP binding site |
Conserved_site | IPR018488 | Cyclic nucleotide-binding, conserved site |
Domain | IPR000595 | Cyclic nucleotide-binding domain |
Domain | IPR000719 | Protein kinase domain |
Domain | IPR000961 | AGC-kinase, C-terminal |
Domain | IPR031831 | cGMP-dependent protein kinase, N-terminal coiled-coil domain |
Domain | IPR035014 | cGMP-dependent protein kinase, catalytic domain |
Family | IPR002374 | cGMP-dependent kinase |
Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Homologous_superfamily | IPR014710 | RmlC-like jelly roll fold |
Homologous_superfamily | IPR018490 | Cyclic nucleotide-binding domain superfamily |
Domain Details Per Protein
Protein | Length | AGC-kinase, C-terminal | cGMP-dependent kinase | cGMP-dependent protein kinase, catalytic domain | cGMP-dependent protein kinase, N-terminal coiled-coil domain | Cyclic nucleotide-binding, conserved site | Cyclic nucleotide-binding domain | Cyclic nucleotide-binding domain superfamily | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | RmlC-like jelly roll fold | Serine/threonine-protein kinase, active site |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q7T2E5
|
667 | ||||||||||||
UniProtKB:A0A8M2B3F1
|
684 |
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
prkg1a-201
(1)
|
Ensembl | 3,095 nt |
Interactions and Pathways
No data available
Plasmids
No data available