Gene
aldh2.1
- ID
- ZDB-GENE-040426-1262
- Name
- aldehyde dehydrogenase 2 family member, tandem duplicate 1
- Symbol
- aldh2.1 Nomenclature History
- Previous Names
-
- aldh2 (1)
- aldh2a
- zgc:63786
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables 3-chloroallyl aldehyde dehydrogenase activity. Predicted to act upstream of or within cellular aldehyde metabolic process. Is expressed in several structures, including fin; heart; liver; musculature system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); diabetic neuropathy; and liver disease (multiple). Orthologous to human ALDH2 (aldehyde dehydrogenase 2 family member).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| zf3854 | Allele with one deletion | Exon 3 | Unknown | CRISPR |
1 - 1 of 1
Show
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR016160 | Aldehyde dehydrogenase, cysteine active site |
| Conserved_site | IPR029510 | Aldehyde dehydrogenase, glutamic acid active site |
| Domain | IPR015590 | Aldehyde dehydrogenase domain |
| Homologous_superfamily | IPR016161 | Aldehyde/histidinol dehydrogenase |
| Homologous_superfamily | IPR016162 | Aldehyde dehydrogenase, N-terminal |
1 - 5 of 6 Show all
Domain Details Per Protein
| Protein | Length | Aldehyde dehydrogenase, C-terminal | Aldehyde dehydrogenase, cysteine active site | Aldehyde dehydrogenase domain | Aldehyde dehydrogenase, glutamic acid active site | Aldehyde dehydrogenase, N-terminal | Aldehyde/histidinol dehydrogenase |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7SXU3
|
516 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
aldh2.1-201
(1)
|
Ensembl | 1,935 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-157P22 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-204G14 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:63786 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200490 (1) | 1940 nt | ||
| Genomic | GenBank:CT978957 | 164556 nt | ||
| Polypeptide | UniProtKB:Q7SXU3 (1) | 516 aa |
- Lu, Y., Travnickova, J., Badonyi, M., Rambow, F., Coates, A., Khan, Z., Marques, J., Murphy, L.C., Garcia-Martinez, P., Marais, R., Louphrasitthiphol, P., Chan, A.H.Y., Schofield, C.J., von Kriegsheim, A., Marsh, J.A., Pavet, V., Sansom, O.J., Illingworth, R.S., Patton, E.E. (2024) ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma. Cell Reports. 43:114406114406
- Mu, A., Cao, Z., Huang, D., Hosokawa, H., Maegawa, S., Takata, M. (2023) Effects of the major formaldehyde catalyzer ADH5 on phenotypes of fanconi anemia zebrafish model. Molecular biology reports. 50(10):8385-8395
- Brunsdon, H., Brombin, A., Peterson, S., Postlethwait, J.H., Patton, E.E. (2022) Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells. Development (Cambridge, England). 149(10):
- Weeks, O., Miller, B.M., Pepe-Mooney, B.J., Oderberg, I.M., Freeburg, S.H., Smith, C.J., North, T.E., Goessling, W. (2022) Embryonic alcohol exposure disrupts the ubiquitin-proteasome system. JCI insight. 7(23):
- Wohlfart, D.P., Lou, B., Middel, C.S., Morgenstern, J., Fleming, T., Sticht, C., Hausser, I., Hell, R., Hammes, H.P., Szendrödi, J., Nawroth, P.P., Kroll, J. (2022) Accumulation of acetaldehyde in aldh2.1-/- zebrafish causes increased retinal angiogenesis and impaired glucose metabolism. Redox Biology. 50:102249
- Leijten, N.M., Bakker, P., Spaink, H.P., den Hertog, J., Lemeer, S. (2021) Thermal Proteome Profiling in Zebrafish Reveals Effects of Napabucasin on Retinoic Acid Metabolism. Molecular & cellular proteomics : MCP. 20:100033
- Lou, B., Boger, M., Bennewitz, K., Sticht, C., Kopf, S., Morgenstern, J., Fleming, T., Hell, R., Yuan, Z., Nawroth, P.P., Kroll, J. (2020) Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans. Redox Biology. 37:101723
- Lodd, E., Wiggenhauser, L.M., Morgenstern, J., Fleming, T.H., Poschet, G., Büttner, M., Tabler, C.T., Wohlfart, D.P., Nawroth, P.P., Kroll, J. (2019) The combination of loss of glyoxalase1 and obesity results in hyperglycemia. JCI insight. 4(12):
- Zhao, Y., Bao, Z., Wan, Z., Fu, Z., Jin, Y. (2019) Polystyrene microplastic exposure disturbs hepatic glycolipid metabolism at the physiological, biochemical, and transcriptomic levels in adult zebrafish. The Science of the total environment. 710:136279
- Hu, Y., Sopko, R., Chung, V., Foos, M., Studer, R.A., Landry, S.D., Liu, D., Rabinow, L., Gnad, F., Beltrao, P., Perrimon, N. (2018) iProteinDB: An Integrative Database of Drosophila Post-translational Modifications.. G3 (Bethesda). 9(1):1-11
1 - 10 of 28
Show