Gene
rars2
- ID
- ZDB-GENE-040426-1244
- Name
- arginyl-tRNA synthetase 2, mitochondrial
- Symbol
- rars2 Nomenclature History
- Previous Names
-
- zgc:63702
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have arginine-tRNA ligase activity. Involved in brain morphogenesis. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 6. Orthologous to human RARS2 (arginyl-tRNA synthetase 2, mitochondrial).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63702 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Kasher et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| pontocerebellar hypoplasia type 6 | Alliance | Pontocerebellar hypoplasia, type 6 | 611523 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001412 | Aminoacyl-tRNA synthetase, class I, conserved site |
| Domain | IPR008909 | DALR anticodon binding |
| Domain | IPR035684 | Arginyl-tRNA synthetase, catalytic core domain |
| Family | IPR001278 | Arginine-tRNA ligase |
| Homologous_superfamily | IPR009080 | Aminoacyl-tRNA synthetase, class Ia, anticodon-binding |
| Homologous_superfamily | IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
Domain Details Per Protein
| Protein | Length | Aminoacyl-tRNA synthetase, class Ia, anticodon-binding | Aminoacyl-tRNA synthetase, class I, conserved site | Arginine-tRNA ligase | Arginyl-tRNA synthetase, catalytic core domain | DALR anticodon binding | Rossmann-like alpha/beta/alpha sandwich fold |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6PGW8
|
597 | ||||||
|
UniProtKB:A0A8M3AVZ0
|
577 |
Interactions and Pathways
No data available
Plasmids
No data available