Gene
cdc14aa
- ID
- ZDB-GENE-040426-1214
- Name
- cell division cycle 14Aa
- Symbol
- cdc14aa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine phosphatase activity. Acts upstream of or within cilium assembly. Located in centrosome and spindle pole. Is expressed in Kupffer's vesicle; forerunner cell group; nervous system; neural tube; and pronephric duct. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 32. Orthologous to human CDC14A (cell division cycle 14A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63654 (18 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 32 | Alliance | Deafness, autosomal recessive 32, with or without immotile sperm | 608653 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000340 | Dual specificity phosphatase, catalytic domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR020422 | Dual specificity protein phosphatase domain |
| Domain | IPR029260 | Dual specificity/tyrosine protein phosphatase, N-terminal |
| Domain | IPR044506 | Dual-specificity phosphatase CDC14, C-terminal |
| Family | IPR050561 | Protein Tyrosine Phosphatase |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
Domain Details Per Protein
| Protein | Length | Dual specificity phosphatase, catalytic domain | Dual-specificity phosphatase CDC14, C-terminal | Dual specificity protein phosphatase domain | Dual specificity/tyrosine protein phosphatase, N-terminal | Protein Tyrosine Phosphatase | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase-like | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BAA8
|
468 | ||||||||
|
UniProtKB:Q7SXZ4
|
592 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cdc14aa-201
(1)
|
Ensembl | 2,562 nt |
Interactions and Pathways
No data available
Plasmids
No data available