Gene
cdc14aa
- ID
- ZDB-GENE-040426-1214
- Name
- cell division cycle 14Aa
- Symbol
- cdc14aa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Involved in cilium assembly. Localizes to centrosome and spindle pole. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 32. Is expressed in Kupffer's vesicle; forerunner cell group; nervous system; neural tube; and pronephric duct. Orthologous to human CDC14A (cell division cycle 14A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63654 (18 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 32 | Alliance | Deafness, autosomal recessive 32, with or without immotile sperm | 608653 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000340 | Dual specificity phosphatase, catalytic domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR020422 | Dual specificity protein phosphatase domain |
| Domain | IPR029260 | Dual specificity/tyrosine protein phosphatase, N-terminal |
| Domain | IPR044506 | Dual-specificity phosphatase CDC14, C-terminal |
| Family | IPR050561 | Protein Tyrosine Phosphatase |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
Domain Details Per Protein
| Protein | Length | Dual specificity phosphatase, catalytic domain | Dual-specificity phosphatase CDC14, C-terminal | Dual specificity protein phosphatase domain | Dual specificity/tyrosine protein phosphatase, N-terminal | Protein Tyrosine Phosphatase | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase-like | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BAA8
|
468 | ||||||||
|
UniProtKB:Q7SXZ4
|
592 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cdc14aa-201
(1)
|
Ensembl | 2,562 nt |
Interactions and Pathways
No data available
Plasmids
No data available