Gene

foxl1

ID

ZDB-GENE-040426-1181

Name

forkhead box L1

Symbol

foxl1 Nomenclature History

Previous Names

zgc:63595

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Exhibits DNA-binding transcription factor activity. Involved in animal organ development; negative regulation of transcription, DNA-templated; and pectoral fin morphogenesis. Predicted to localize to nucleus. Is expressed in several structures, including brain; digestive system; head; pleuroperitoneal region; and presumptive neural retina. Orthologous to human FOXL1 (forkhead box L1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With foxl1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
otosclerosis 11	Alliance	Otosclerosis 11	620576

Associated With foxl1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
otosclerosis	foxl1^nfl1/nfl1 (AB)	standard conditions	Hawkey-Noble et al., 2022
osteoporosis	foxl1^nfl1/nfl1 (AB)	standard conditions	Hawkey-Noble et al., 2022

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018122	Fork head domain conserved site1
Conserved_site	IPR030456	Fork head domain conserved site 2
Domain	IPR001766	Fork head domain
Domain	IPR047514	Forkhead box protein L1, forkhead domain
Family	IPR050211	Forkhead box domain-containing protein
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily