Gene
ptpn11b
- ID
- ZDB-GENE-040426-1158
- Name
- protein tyrosine phosphatase non-receptor type 11b
- Symbol
- ptpn11b Nomenclature History
- Previous Names
-
- SHP3 (1)
- zgc:63553
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Enables phosphatase activity. Acts upstream of or within embryonic viscerocranium morphogenesis. Predicted to be active in cytoplasm. Is expressed in head. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 1; atrophic gastritis; juvenile myelomonocytic leukemia; and metachondromatosis. Orthologous to human PTPN11 (protein tyrosine phosphatase non-receptor type 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| juvenile myelomonocytic leukemia | Alliance | Leukemia, juvenile myelomonocytic, somatic | 607785 |
| metachondromatosis | Alliance | Metachondromatosis | 156250 |
| Noonan syndrome 1 | Alliance | Noonan syndrome 1 | 163950 |
| Noonan syndrome with multiple lentigines 1 | Alliance | LEOPARD syndrome 1 | 151100 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000242 | Tyrosine-specific protein phosphatase, PTPase domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
| Family | IPR012152 | Protein-tyrosine phosphatase, non-receptor type-6, -11 |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Length | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Protein-tyrosine phosphatase, non-receptor type-6, -11 | SH2 domain | SH2 domain superfamily | Tyrosine-specific protein phosphatase, PTPase domain | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3AYC9
|
422 | ||||||||
|
UniProtKB:Q7SY37
|
592 | ||||||||
|
UniProtKB:S6CMQ2
|
590 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptpn11b-201
(1)
|
Ensembl | 3,241 nt |
Interactions and Pathways
No data available
Plasmids
No data available