Gene

asl

ID

ZDB-GENE-040426-1152

Name

argininosuccinate lyase

Symbol

asl Nomenclature History

Previous Names

zgc:63532 (1)

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have argininosuccinate lyase activity. Predicted to be involved in arginine biosynthetic process via ornithine. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and argininosuccinic aciduria. Is expressed in several structures, including ball; lens; liver; pronephric duct; and solid lens vesicle. Orthologous to human ASL (argininosuccinate lyase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:63532 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With asl Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
argininosuccinic aciduria	Alliance	Argininosuccinic aciduria	207900

Associated With asl Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020557	Fumarate lyase, conserved site
Domain	IPR022761	Fumarate lyase, N-terminal
Domain	IPR029419	Argininosuccinate lyase, C-terminal
Family	IPR000362	Fumarate lyase family
Family	IPR009049	Argininosuccinate lyase
Homologous_superfamily	IPR008948	L-Aspartase-like
Homologous_superfamily	IPR024083	Fumarase/histidase, N-terminal

Domain Details Per Protein

Protein	Length	Argininosuccinate lyase	Argininosuccinate lyase, C-terminal	Fumarase/histidase, N-terminal	Fumarate lyase, conserved site	Fumarate lyase family	Fumarate lyase, N-terminal	L-Aspartase-like
UniProtKB:F1RA91 InterPro	465
UniProtKB:Q7SY44 InterPro	465

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	asl-201 (1) Ensembl	Ensembl	1,811 nt	Select Tool
mRNA	asl-202 (1) Ensembl	Ensembl	835 nt	Select Tool
mRNA	asl-203 (1) Ensembl	Ensembl	4,694 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations