Gene
pik3cd
- ID
- ZDB-GENE-040426-1128
- Name
- phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
- Symbol
- pik3cd Nomenclature History
- Previous Names
-
- zgc:63473 (1)
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in regulation of collateral sprouting in absence of injury. Predicted to localize to cytoplasm; phosphatidylinositol 3-kinase complex; and plasma membrane. Human ortholog(s) of this gene implicated in colorectal cancer; endometrial cancer; and primary immunodeficiency disease. Is expressed in central nervous system and cranial ganglion. Orthologous to human PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63473 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Schmidt et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
immunodeficiency 14 | Alliance | Immunodeficiency 14A, autosomal dominant | 615513 |
Immunodeficiency 14B, autosomal recessive | 619281 | ||
?Roifman-Chitayat syndrome, digenic | 613328 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR018936 | Phosphatidylinositol 3/4-kinase, conserved site |
Domain | IPR000341 | Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain |
Domain | IPR000403 | Phosphatidylinositol 3-/4-kinase, catalytic domain |
Domain | IPR001263 | Phosphoinositide 3-kinase, accessory (PIK) domain |
Domain | IPR002420 | C2 phosphatidylinositol 3-kinase-type domain |
Domain | IPR003113 | Phosphatidylinositol 3-kinase, adaptor-binding domain |
Domain | IPR037703 | PI3Kdelta, catalytic domain |
Family | IPR015433 | Phosphatidylinositol kinase |
Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Homologous_superfamily | IPR016024 | Armadillo-type fold |
Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
Homologous_superfamily | IPR035892 | C2 domain superfamily |
Homologous_superfamily | IPR036940 | Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily |
Homologous_superfamily | IPR042236 | Phosphoinositide 3-kinase, accessory (PIK) domain superfamily |
Domain Details Per Protein
Protein | Length | Armadillo-type fold | C2 domain superfamily | C2 phosphatidylinositol 3-kinase-type domain | Phosphatidylinositol 3-/4-kinase, catalytic domain | Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily | Phosphatidylinositol 3/4-kinase, conserved site | Phosphatidylinositol 3-kinase, adaptor-binding domain | Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain | Phosphatidylinositol kinase | Phosphoinositide 3-kinase, accessory (PIK) domain | Phosphoinositide 3-kinase, accessory (PIK) domain superfamily | PI3Kdelta, catalytic domain | Protein kinase-like domain superfamily | Ubiquitin-like domain superfamily |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q7SYE7
|
1039 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available