Gene
fancl
- ID
- ZDB-GENE-040426-1045
- Name
- FA complementation group L
- Symbol
- fancl Nomenclature History
- Previous Names
-
- zgc:66144
- zgc:76938
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to have ubiquitin protein ligase activity. Involved in oocyte development. Predicted to localize to nucleus. Is expressed in central nervous system; eye; heart; intermediate cell mass of mesoderm; and reproductive system. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group L. Orthologous to human FANCL (FA complementation group L).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66144 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ramanagoudr-Bhojappa et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Fanconi anemia complementation group L | Alliance | Fanconi anemia, complementation group L | 614083 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR001841 | Zinc finger, RING-type |
Domain | IPR019162 | Fanconi anemia complex, subunit FancL, WD-repeat containing domain |
Domain | IPR026850 | FANCL C-terminal domain |
Domain | IPR043898 | FANCL, UBC-like domain 2 |
Domain | IPR044037 | FANCL, UBC-like domain 3 |
Family | IPR026848 | E3 ubiquitin-protein ligase FANCL |
Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
Homologous_superfamily | IPR016135 | Ubiquitin-conjugating enzyme/RWD-like |
Homologous_superfamily | IPR043003 | FANCL, UBC-like domain 3 superfamily |
Domain Details Per Protein
Protein | Length | E3 ubiquitin-protein ligase FANCL | FANCL C-terminal domain | FANCL, UBC-like domain 2 | FANCL, UBC-like domain 3 | FANCL, UBC-like domain 3 superfamily | Fanconi anemia complex, subunit FancL, WD-repeat containing domain | Ubiquitin-conjugating enzyme/RWD-like | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9Q9M3
|
316 | |||||||||
UniProtKB:Q6NY39
|
371 |
Interactions and Pathways
No data available
Plasmids
No data available