Gene
mttp
- ID
- ZDB-GENE-040419-2
- Name
- microsomal triglyceride transfer protein
- Symbol
- mttp Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable phosphatidylethanolamine transfer activity. Acts upstream of or within several processes, including lipid transport; lipoprotein biosynthetic process; and sprouting angiogenesis. Predicted to be active in Golgi apparatus; basolateral plasma membrane; and endoplasmic reticulum. Is expressed in several structures, including gut; liver; marginal blastomere; testis; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including abdominal obesity-metabolic syndrome 1; abetalipoproteinemia; familial hypercholesterolemia; hyperinsulinism; and obesity. Orthologous to human MTTP (microsomal triglyceride transfer protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7141221 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| c655 | Allele with one point mutation | Exon 15 | Missense | spontaneous | |
| sa11757 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32615 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| y79 | Allele with one point mutation | Exon 11 | Missense | not specified | |
| zko254a | Allele with one delins | Unknown | Unknown | CRISPR | |
| zko262b | Allele with one delins | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mttp | China Zebrafish Resource Center (CZRC) | |
| MO1-mttp | N/A | (4) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| abetalipoproteinemia | Alliance | Abetalipoproteinemia | 200100 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001747 | Vitellogenin, N-terminal |
| Domain | IPR045811 | MTP large subunit, lipid-binding domain |
| Family | IPR039988 | Microsomal triglyceride transfer protein large subunit |
| Homologous_superfamily | IPR011030 | Lipovitellin-phosvitin complex, superhelical domain |
| Homologous_superfamily | IPR015816 | Vitellinogen, beta-sheet N-terminal |
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Domain Details Per Protein
| Protein | Length | Lipid transport protein, beta-sheet shell | Lipovitellin-phosvitin complex, superhelical domain | Microsomal triglyceride transfer protein large subunit | MTP large subunit, lipid-binding domain | Vitellinogen, beta-sheet N-terminal | Vitellogenin, N-terminal |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IVV0
|
884 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-58J15 | ZFIN Curated Data | |
| Encodes | EST | fd36b01 | ||
| Encodes | EST | IMAGE:7141221 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:111876 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136353 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:162558 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212970 (1) | 3149 nt | ||
| Genomic | GenBank:BX908747 (1) | 232503 nt | ||
| Polypeptide | UniProtKB:A0A0R4IVV0 (1) | 884 aa |
- Comparative Orthology
- Alliance
- Li, X., Liu, C., Zhang, R., Li, Y., Ye, D., Wang, H., He, M., Sun, Y. (2024) Biosynthetic deficiency of docosahexaenoic acid causes nonalcoholic fatty liver disease and ferroptosis-mediated hepatocyte injury. The Journal of biological chemistry. 300(7):107405
- Le Mentec, H., Monniez, E., Legrand, A., Monvoisin, C., Lagadic-Gossmann, D., Podechard, N. (2023) A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation. International Journal of Molecular Sciences. 24(4):
- Zhang, Z.F., Song, T.T., Chen, J.F., Lv, G.Y. (2023) Recovery of a hypolipidemic polysaccharide from artificially cultivated Sanghuangporus vaninii with an effective method. Frontiers in nutrition. 9:10955561095556
- Buerger, A.N., Parente, C.E., Harris, J.P., Watts, E.G., Wormington, A.M., Bisesi, J.H. (2022) Impacts of diethylhexyl phthalate and overfeeding on physical fitness and lipid mobilization of Danio rerio (zebrafish). Chemosphere. 295:133703
- Chen, Q., Wei, T., Yang, B., Li, S., Ge, L., Zhou, A., Xie, S. (2022) The Impact of Deleting the mitfa gene in Zebrafish on the Intestinal Microbiota Community. Gene. 846:146870
- Dai, W., Wang, K., Zhen, X., Huang, Z., Liu, L. (2022) Magnesium isoglycyrrhizinate attenuates acute alcohol-induced hepatic steatosis in a zebrafish model by regulating lipid metabolism and ER stress. Nutrition & metabolism. 19:23
- Hu, C., Sun, B., Liu, M., Yu, J., Zhou, X., Chen, L. (2022) Fecal transplantation from young zebrafish donors efficiently ameliorates the lipid metabolism disorder of aged recipients exposed to perfluorobutanesulfonate. The Science of the total environment. 823:153758
- Ivanovics, B., Gazsi, G., Reining, M., Berta, I., Poliska, S., Toth, M., Domokos, A., Nagy, B., Staszny, A., Cserhati, M., Csosz, E., Bacsi, A., Csenki-Bakos, Z., Acs, A., Urbanyi, B., Czimmerer, Z. (2021) Embryonic exposure to low concentrations of aflatoxin B1 triggers global transcriptomic changes, defective yolk lipid mobilization, abnormal gastrointestinal tract development and inflammation in zebrafish. Journal of hazardous materials. 416:125788
- Templehof, H., Moshe, N., Avraham-Davidi, I., Yaniv, K. (2021) Zebrafish mutants provide insights into Apolipoprotein B functions during embryonic development and pathological conditions. JCI insight. 6(13):
- Zhang, W., Wu, C., Ni, R., Yang, Q., Luo, L., He, J. (2021) Formimidoyltransferase cyclodeaminase prevents the starvation-induced liver hepatomegaly and dysfunction through downregulating mTORC1. PLoS Genetics. 17:e1009980
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