Gene
mttp
- ID
- ZDB-GENE-040419-2
- Name
- microsomal triglyceride transfer protein
- Symbol
- mttp Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable phosphatidylethanolamine transfer activity. Acts upstream of or within several processes, including lipid transport; lipoprotein biosynthetic process; and sprouting angiogenesis. Predicted to be active in Golgi apparatus; basolateral plasma membrane; and endoplasmic reticulum. Is expressed in several structures, including gut; liver; marginal blastomere; testis; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including abdominal obesity-metabolic syndrome 1; abetalipoproteinemia; familial hypercholesterolemia; hyperinsulinism; and obesity. Orthologous to human MTTP (microsomal triglyceride transfer protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7141221 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| abetalipoproteinemia | Alliance | Abetalipoproteinemia | 200100 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001747 | Vitellogenin, N-terminal |
| Domain | IPR045811 | MTP large subunit, lipid-binding domain |
| Family | IPR039988 | Microsomal triglyceride transfer protein large subunit |
| Homologous_superfamily | IPR011030 | Lipovitellin-phosvitin complex, superhelical domain |
| Homologous_superfamily | IPR015816 | Vitellinogen, beta-sheet N-terminal |
| Homologous_superfamily | IPR015819 | Lipid transport protein, beta-sheet shell |
Domain Details Per Protein
| Protein | Length | Lipid transport protein, beta-sheet shell | Lipovitellin-phosvitin complex, superhelical domain | Microsomal triglyceride transfer protein large subunit | MTP large subunit, lipid-binding domain | Vitellinogen, beta-sheet N-terminal | Vitellogenin, N-terminal |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IVV0
|
884 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance