Gene

cbx4

ID

ZDB-GENE-040329-2

Name

chromobox homolog 4 (Pc class homolog, Drosophila)

Symbol

cbx4 Nomenclature History

Previous Names

im:6911625
zgc:158588

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to enable SUMO binding activity and SUMO ligase activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and protein sumoylation. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of PRC1 complex. Is expressed in several structures, including digestive system; eye; heart; pectoral fin bud; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human CBX4 (chromobox 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6911625 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cbx4 Human Ortholog

No data available

Associated With cbx4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023779	Chromo domain, conserved site
Conserved_site	IPR033773	CBX family C-terminal motif
Domain	IPR000953	Chromo/chromo shadow domain
Domain	IPR017984	Chromo domain subgroup
Domain	IPR023780	Chromo domain
Family	IPR043531	E3 SUMO-protein ligase CBX4
Homologous_superfamily	IPR016197	Chromo-like domain superfamily