Gene
hcrt
- ID
- ZDB-GENE-040324-1
- Name
- hypocretin (orexin) neuropeptide precursor
- Symbol
- hcrt Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have neuropeptide hormone activity; type 1 hypocretin receptor binding activity; and type 2 hypocretin receptor binding activity. Involved in several processes, including circadian sleep/wake cycle, wakefulness; multicellular organismal response to stress; and sleep. Predicted to localize to perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in narcolepsy. Is expressed in brain; female organism; hypocretin-secreting neurons; male organism; and spinal cord. Orthologous to human HCRT (hypocretin neuropeptide precursor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 50 figures from 35 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Nishimura et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| narcolepsy | Alliance | ?Narcolepsy 1 | 161400 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR001704 | Prepro-orexin |
Domain Details Per Protein
| Protein | Length | Prepro-orexin |
|---|---|---|
|
UniProtKB:Q0PIA1
|
129 |
Interactions and Pathways
No data available
Plasmids