Gene
traf4a
- ID
- ZDB-GENE-040308-1
- Name
- tnf receptor-associated factor 4a
- Symbol
- traf4a Nomenclature History
- Previous Names
-
- traf4l
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin protein ligase binding activity. Acts upstream of or within establishment of epithelial cell apical/basal polarity; optic cup morphogenesis involved in camera-type eye development; and optic vesicle elongation. Predicted to be located in cytoplasm. Is expressed in several structures, including axial blood vessel; digestive system; immature eye; mesoderm; and nervous system. Orthologous to human TRAF4 (TNF receptor associated factor 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu286 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Hehr et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ca301 | Allele with one deletion | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | MATH/TRAF domain | TNF receptor-associated factor 4, MATH domain | TNF receptor-associated factor TRAF, metazoa | TRAF1-6, MATH domain | TRAF-like | Zinc finger, C3HC4 RING-type | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site | Zinc finger, TRAF-type |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7T1K2
|
470 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
traf4a-201
(1)
|
Ensembl | 3,072 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-187B9 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-81N5 | ZFIN Curated Data | |
| Encodes | EST | eu286 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:77418 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_205762 (1) | 3090 nt | ||
| Genomic | GenBank:CR392353 (1) | 183599 nt | ||
| Polypeptide | UniProtKB:Q7T1K2 (1) | 470 aa |
- Conant, G.C. (2020) The lasting after-effects of an ancient polyploidy on the genomes of teleosts. PLoS One. 15:e0231356
- Lange, C., Rost, F., Machate, A., Reinhardt, S., Lesche, M., Weber, A., Kuscha, V., Dahl, A., Rulands, S., Brand, M. (2020) Single cell sequencing of radial glia progeny reveals diversity of newborn neurons in the adult zebrafish brain. Development (Cambridge, England). 147(1):
- Hehr, C.L., Halabi, R., McFarlane, S. (2018) Polarity and morphogenesis of the eye epithelium requires the adhesion junction associated adaptor protein Traf4. Cell adhesion & migration. 12(5):489-502
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Miao, L., Yuan, Y., Cheng, F., Fang, J., Zhou, F., Ma, W., Jiang, Y., Huang, X., Wang, Y., Shan, L., Chen, D., Zhang, J. (2017) Translation repression by maternal RNA binding protein zar1 is essential for early oogenesis in zebrafish. Development (Cambridge, England). 144(1):128-138
- Mandriani, B., Castellana, S., Rinaldi, C., Manzoni, M., Venuto, S., Rodriguez-Aznar, E., Galceran, J., Nieto, M.A., Borsani, G., Monti, E., Mazza, T., Merla, G., Micale, L. (2016) Identification of p53-target genes in Danio rerio. Scientific Reports. 6:32474
- Liu, C., Xu, H., Lam, S.H., and Gong, Z. (2013) Selection of Reliable Biomarkers from PCR Array Analyses Using Relative Distance Computational Model: Methodology and Proof-of-Concept Study. PLoS One. 8(12):e83954
- Xu, Z.Y., Sun, B.J., Chang, M.X., and Nie, P. (2008) Characterization and expression analysis of TNFR-associated factor 1 (TRAF1) in grass carp Ctenopharyngodon idella. Veterinary Immunology and Immunopathology. 121(1-2):44-57
- Stein, C., Caccamo, M., Laird, G., and Leptin, M. (2007) Conservation and divergence of gene families encoding components of innate immune response systems in the zebrafish. Genome biology. 8(11):R251
- Kedinger, V., Alpy, F., Tomasetto, C., Thisse, C., Thisse, B., and Rio, M.C. (2005) Spatial and temporal distribution of the traf4 genes during zebrafish development. Gene expression patterns : GEP. 5(4):545-552
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