Gene
tlr4bb
- ID
- ZDB-GENE-040219-9
- Name
- toll-like receptor 4b, duplicate b
- Symbol
- tlr4bb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable lipopolysaccharide binding activity and lipopolysaccharide immune receptor activity. Acts upstream of or within positive regulation of hematopoietic progenitor cell differentiation. Predicted to be located in cytoplasm and membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including blood; forebrain neural keel; nervous system; neural rod; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including allergic contact dermatitis (multiple); artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human TLR4 (toll like receptor 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu723 (1 image)
- eu724 (23 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from He et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fh307 | Allele with one point mutation | Unknown | Unknown | ENU | |
| fh308 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa9527 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12965 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15774 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31917 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31918 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35456 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa35457 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tlr4bb_unrecovered | Allele with one point mutation | Unknown | Unknown | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000157 | Toll/interleukin-1 receptor homology (TIR) domain |
| Family | IPR017241 | Toll-like receptor |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Homologous_superfamily | IPR035897 | Toll/interleukin-1 receptor homology (TIR) domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
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Domain Details Per Protein
| Protein | Length | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype | Toll/interleukin-1 receptor homology (TIR) domain | Toll/interleukin-1 receptor homology (TIR) domain superfamily | Toll-like receptor |
|---|---|---|---|---|---|---|---|
|
UniProtKB:B8A691
|
819 | ||||||
|
UniProtKB:Q6TS41
|
819 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tlr4bb-201
(1)
|
Ensembl | 2,736 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-198A12 | ZFIN Curated Data | |
| Encodes | EST | eu723 | Thisse et al., 2005 | |
| Encodes | EST | eu724 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:85690 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212813 (1) | 2740 nt | ||
| Genomic | GenBank:BX928754 (1) | 263849 nt | ||
| Polypeptide | UniProtKB:B8A691 (1) | 819 aa |
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- Authors in Sullivan C et al (ZDB-PUB-091023-26) state: "The strong conclusion from the analysis of conserved syntenies is that the zebrafish genes called tlr4a and tlr4b are not orthologs of the human TLR4 gene, but represent a reciprocal loss of ohnologs derived from the second round of genome duplication at about the time of the vertebrate radiation. The implication of orthology can be avoided where none exists by calling the zebrafish genes tlr4ba and tlr4bb, and the human gene TLR4A.
No data available
- Weiss, A., D'Amata, C., Pearson, B.J., Hayes, M.N. (2024) A syngeneic spontaneous zebrafish model of tp53-deficient, EGFRvIII, and PI3KCAH1047R-driven glioblastoma reveals inhibitory roles for inflammation during tumor initiation and relapse in vivo. eLIFE. 13:
- Zhang, Z., Zhang, H.L., Yang, D.H., Hao, Q., Yang, H.W., Meng, D.L., Meindert de Vos, W., Guan, L.L., Liu, S.B., Teame, T., Gao, C.C., Ran, C., Yang, Y.L., Yao, Y.Y., Ding, Q.W., Zhou, Z.G. (2024) Lactobacillus rhamnosus GG triggers intestinal epithelium injury in zebrafish revealing host dependent beneficial effects. iMeta. 3:e181e181
- Bian, W.P., Xie, S.L., Wang, C., Martinovich, G.G., Ma, Y.B., Jia, P.P., Pei, D.S. (2023) mitfa deficiency promotes immune vigor and potentiates antitumor effects in zebrafish. Fish & shellfish immunology. 142:109130
- Wu, J., Lin, X., Wu, D., Yan, B., Bao, M., Zheng, P., Wang, J., Yang, C., Li, Z., Jin, X., Jiang, K. (2023) Poly(I:C)-exposed zebrafish shows autism-like behaviors which are ameliorated by fabp2 gene knockout. Frontiers in molecular neuroscience. 15:10680191068019
- Chen, Q., Wei, T., Yang, B., Li, S., Ge, L., Zhou, A., Xie, S. (2022) The Impact of Deleting the mitfa gene in Zebrafish on the Intestinal Microbiota Community. Gene. 846:146870
- Ma, K., Chen, S., Wu, Y., Ma, Y., Qiao, H., Fan, J., Wu, H. (2022) Dietary supplementation with microalgae enhances the zebrafish growth performance by modulating immune status and gut microbiota. Applied Microbiology and Biotechnology. 106(2):773-788
- Tyrkalska, S.D., Martínez-López, A., Pedoto, A., Candel, S., Cayuela, M.L., Mulero, V. (2022) The Spike protein of SARS-CoV-2 signals via Tlr2 in zebrafish. Developmental and comparative immunology. 140:104626
- Xiao, X., Liu, Z., Su, G., Liu, H., Yin, W., Guan, Y., Jing, S., Du, L., Li, F., Li, N., Yang, P. (2022) A novel uveitis model induced by lipopolysaccharide in zebrafish. Frontiers in immunology. 13:10428491042849
- Chen, J., Tchivelekete, G.M., Zhou, X., Tang, W., Liu, F., Liu, M., Zhao, C., Shu, X., Zeng, Z. (2021) Anti-inflammatory activities of Gardenia jasminoides extracts in retinal pigment epithelial cells and zebrafish embryos. Experimental and Therapeutic Medicine. 22:700
- Chen, Z., Zhijie, C., Yuting, Z., Chan, L., Shilin, X., Qichun, Z., Jinying, O., Jing, L., Chaohua, L., Zhixian, M. (2021) The Ameliorative Effects of Isorhynchophylline on Morphine Dependence Are Mediated Through the Microbiota-Gut-Brain Axis. Frontiers in pharmacology. 12:526923
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