Gene
tlr4ba
- ID
- ZDB-GENE-040219-8
- Name
- toll-like receptor 4b, duplicate a
- Symbol
- tlr4ba Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to have signaling receptor activity. Predicted to be involved in inflammatory response and toll-like receptor signaling pathway. Localizes to protein-containing complex. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetes mellitus (multiple); eye disease (multiple); lung disease (multiple); and vasculitis (multiple). Is expressed in several structures, including blood; heart; integument; liver; and pleuroperitoneal region. Orthologous to human TLR4 (toll like receptor 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000157 | Toll/interleukin-1 receptor homology (TIR) domain |
| Family | IPR017241 | Toll-like receptor |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Homologous_superfamily | IPR035897 | Toll/interleukin-1 receptor homology (TIR) domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
| Repeat | IPR003591 | Leucine-rich repeat, typical subtype |
| Repeat | IPR026906 | BspA-type LRR region |
Domain Details Per Protein
| Protein | Length | BspA-type LRR region | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype | Toll/interleukin-1 receptor homology (TIR) domain | Toll/interleukin-1 receptor homology (TIR) domain superfamily | Toll-like receptor |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3B7X7
|
824 | |||||||
|
UniProtKB:B3U3W0
|
750 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tlr4ba-201
(1)
|
Ensembl | 2,328 nt | ||
| mRNA |
tlr4ba-202
(1)
|
Ensembl | 2,553 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- Orthology with AA evidence from Jault C et al (Mol Immunol 40(11), 759-771; ZDB-PUB-040109-34) was deleted in light of data in Sullivan C et al (ZDB-PUB-091023-26). The authors state: "The strong conclusion from the analysis of conserved syntenies is that the zebrafish genes called tlr4a and tlr4b are not orthologs of the human TLR4 gene, but represent a reciprocal loss of ohnologs derived from the second round of genome duplication at about the time of the vertebrate radiation. The implication of orthology can be avoided where none exists by calling the zebrafish genes tlr4ba and tlr4bb, and the human gene TLR4A.