Gene
myd88
- ID
- ZDB-GENE-040219-3
- Name
- MYD88 innate immune signal transduction adaptor
- Symbol
- myd88 Nomenclature History
- Previous Names
-
- zMyD88 (1)
- zgc:103541
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to have Toll-like receptor binding activity. Involved in several processes, including neutrophil activation involved in immune response; neutrophil chemotaxis; and response to bacterium. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in Waldenstroem's macroglobulinemia. Is expressed in several structures, including digestive system; hematopoietic system; pleuroperitoneal region; tail bud; and ventral fin fold. Orthologous to human MYD88 (MYD88 innate immune signal transduction adaptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 9 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
lymphoplasmacytic lymphoma | Alliance | Macroglobulinemia, Waldenstrom, somatic | 153600 |
Immunodeficiency 68 | 612260 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000157 | Toll/interleukin-1 receptor homology (TIR) domain |
Domain | IPR000488 | Death domain |
Domain | IPR034249 | MyD88, death domain |
Family | IPR017281 | Myeloid differentiation primary response protein MyD88 |
Homologous_superfamily | IPR011029 | Death-like domain superfamily |
Homologous_superfamily | IPR035897 | Toll/interleukin-1 receptor homology (TIR) domain superfamily |
Domain Details Per Protein
Protein | Length | Death domain | Death-like domain superfamily | MyD88, death domain | Myeloid differentiation primary response protein MyD88 | Toll/interleukin-1 receptor homology (TIR) domain | Toll/interleukin-1 receptor homology (TIR) domain superfamily |
---|---|---|---|---|---|---|---|
UniProtKB:Q5XJ85
|
284 | ||||||
UniProtKB:B2GQ86
|
284 |
Interactions and Pathways
No data available
Plasmids
No data available