Gene
tlr5b
- ID
- ZDB-GENE-040219-15
- Name
- toll-like receptor 5b
- Symbol
- tlr5b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable signaling receptor activity. Involved in toll-like receptor 5 signaling pathway. Acts upstream of or within toll-like receptor signaling pathway. Predicted to be located in cytoplasm and membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Legionnaires' disease; cystic fibrosis; cystitis; melioidosis; and systemic lupus erythematosus. Orthologous to human TLR5 (toll like receptor 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la013935Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa6655 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16424 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000157 | Toll/interleukin-1 receptor homology (TIR) domain |
| Domain | IPR000483 | Cysteine-rich flanking region, C-terminal |
| Family | IPR017241 | Toll-like receptor |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Homologous_superfamily | IPR035897 | Toll/interleukin-1 receptor homology (TIR) domain superfamily |
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Domain Details Per Protein
| Protein | Length | Cysteine-rich flanking region, C-terminal | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype | Toll/interleukin-1 receptor homology (TIR) domain | Toll/interleukin-1 receptor homology (TIR) domain superfamily | Toll-like receptor |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F8W3J5
|
881 | |||||||
|
UniProtKB:B3DIN1
|
875 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-471M19 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195156 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195169 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001130595 (1) | 2763 nt | ||
| Genomic | GenBank:FP017156 (2) | 41257 nt | ||
| Polypeptide | UniProtKB:F8W3J5 (1) | 881 aa |
- Zhang, Z., Zhang, H.L., Yang, D.H., Hao, Q., Yang, H.W., Meng, D.L., Meindert de Vos, W., Guan, L.L., Liu, S.B., Teame, T., Gao, C.C., Ran, C., Yang, Y.L., Yao, Y.Y., Ding, Q.W., Zhou, Z.G. (2024) Lactobacillus rhamnosus GG triggers intestinal epithelium injury in zebrafish revealing host dependent beneficial effects. iMeta. 3:e181e181
- Bian, W.P., Xie, S.L., Wang, C., Martinovich, G.G., Ma, Y.B., Jia, P.P., Pei, D.S. (2023) mitfa deficiency promotes immune vigor and potentiates antitumor effects in zebrafish. Fish & shellfish immunology. 142:109130
- Zhang, C., Zhao, Z., Jia, Y.J., Zhang, P.Q., Sun, Y., Zhou, Y.C., Wang, G.X., Zhu, B. (2023) Rationally Designed Self-Assembling Nanovaccines Elicit Robust Mucosal and Systemic Immunity against Rhabdovirus. ACS applied materials & interfaces. 16(1):228-244
- Deng, Z., Hou, K., Valencak, T.G., Luo, X.M., Liu, J., Wang, H. (2022) AI-2/LuxS Quorum Sensing System Promotes Biofilm Formation of Lactobacillus rhamnosus GG and Enhances the Resistance to Enterotoxigenic Escherichia coli in Germ-Free Zebrafish. Microbiology spectrum. 10(4):e0061022
- Ma, K., Chen, S., Wu, Y., Ma, Y., Qiao, H., Fan, J., Wu, H. (2022) Dietary supplementation with microalgae enhances the zebrafish growth performance by modulating immune status and gut microbiota. Applied Microbiology and Biotechnology. 106(2):773-788
- Xiao, X., Liu, Z., Su, G., Liu, H., Yin, W., Guan, Y., Jing, S., Du, L., Li, F., Li, N., Yang, P. (2022) A novel uveitis model induced by lipopolysaccharide in zebrafish. Frontiers in immunology. 13:10428491042849
- Zhang, W., Chen, L., Feng, H., Wang, J., Zeng, F., Xiao, X., Jian, J., Wang, N., Pang, H. (2022) Functional characterization of Vibrio alginolyticus T3SS regulator ExsA and evaluation of its mutant as a live attenuated vaccine candidate in zebrafish (Danio rerio) model. Frontiers in veterinary science. 9:938822938822
- Zhang, X., Ivantsova, E., Perez-Rodriguez, V., Cao, F., Souders, C.L., Martyniuk, C.J. (2022) Investigating mitochondria-immune responses in zebrafish, Danio rerio (Hamilton, 1822): A case study with the herbicide dinoseb. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 257:109357
- Campbell, C.A., Fursova, O., Cheng, X., Snella, E., McCune, A., Li, L., Solchenberger, B., Schmid, B., Sahoo, D., Morton, M., Traver, D., Espín-Palazón, R. (2021) A zebrafish model of granulin deficiency reveals essential roles in myeloid cell differentiation. Blood advances. 5:796-811
- Shan, S., Liu, R., Feng, H., Meng, F., Aizaz, M., Yang, G. (2021) Identification and functional characterization of a fish-specific tlr19 in common carp (Cyprinus carpio L.) that recruits TRIF as an adaptor and induces ifn expression during the immune response. Veterinary research. 52:88
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