Gene
tlr7
- ID
- ZDB-GENE-040219-11
- Name
- toll-like receptor 7
- Symbol
- tlr7 Nomenclature History
- Previous Names
-
- TLR7A (1)
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable single-stranded RNA binding activity and transmembrane signaling receptor activity. Predicted to act upstream of or within defense response to other organism; inflammatory response; and pattern recognition receptor signaling pathway. Predicted to be located in cytoplasm; cytoskeleton; and membrane. Is expressed in several structures, including blood; heart; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in COVID-19; X-Linked immunodeficiency 74; and non-syndromic X-linked intellectual disability 104. Orthologous to several human genes including FRMPD4 (FERM and PDZ domain containing 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa7215 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11566 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31752 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41556 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44716 | Allele with one point mutation | Unknown | Unknown | ENU | |
| zf2185 | Allele with one deletion | Unknown | Unknown | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| X-Linked immunodeficiency 74 | Alliance | Immunodeficiency 74, COVID19-related, X-linked | 301051 |
| Systemic lupus erythematosus 17 | 301080 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000157 | Toll/interleukin-1 receptor homology (TIR) domain |
| Domain | IPR000483 | Cysteine-rich flanking region, C-terminal |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Homologous_superfamily | IPR035897 | Toll/interleukin-1 receptor homology (TIR) domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
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Domain Details Per Protein
| Protein | Length | Cysteine-rich flanking region, C-terminal | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype | Toll/interleukin-1 receptor homology (TIR) domain | Toll/interleukin-1 receptor homology (TIR) domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QKF3
|
1036 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021479060 (1) | 3317 nt | ||
| Genomic | GenBank:CU914164 (1) | 141464 nt | ||
| Polypeptide | UniProtKB:A0A8M9QKF3 (1) | 1036 aa |