Gene
fgfrl1a
- ID
- ZDB-GENE-040128-2
- Name
- fibroblast growth factor receptor like 1a
- Symbol
- fgfrl1a Nomenclature History
- Previous Names
-
- fgfrl1
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable fibroblast growth factor binding activity and fibroblast growth factor receptor activity. Acts upstream of or within several processes, including cartilage development; swim bladder development; and ventricular system development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including digestive system; immature eye; mesoderm; nervous system; and pharyngeal arch. Orthologous to human FGFRL1 (fibroblast growth factor receptor like 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64084 (10 images)
- eu61 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Hall et al., 2006
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Fibroblast growth factor receptor-like | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7SX76
|
483 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
fgfrl1a-201
(1)
|
Ensembl | 3,132 nt |
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Interactions and Pathways
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-13A5 | ZFIN Curated Data | |
| Contained in | BAC | CH211-159I8 | ZFIN Curated Data | |
| Contained in | BAC | CH211-262E22 | ZFIN Curated Data | |
| Encodes | EST | eu61 | Thisse et al., 2005 | |
| Encodes | cDNA | cssl:d155 | Bushell et al., 2007 | |
| Encodes | cDNA | MGC:64084 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200376 (1) | 2774 nt | ||
| Genomic | GenBank:BX004830 (1) | 201070 nt | ||
| Polypeptide | UniProtKB:Q7SX76 (1) | 483 aa |
- Abu Nahia, K., Migdał, M., Quinn, T.A., Poon, K.L., Łapiński, M., Sulej, A., Liu, J., Mondal, S.S., Pawlak, M., Bugajski, Ł., Piwocka, K., Brand, T., Kohl, P., Korzh, V., Winata, C. (2021) Genomic and physiological analyses of the zebrafish atrioventricular canal reveal molecular building blocks of the secondary pacemaker region. Cellular and molecular life sciences : CMLS. 78(19-20):6669-6687
- Gallegos, T.F., Kamei, C.N., Rohly, M., Drummond, I.A. (2019) Fibroblast growth factor signaling mediates progenitor cell aggregation and nephron regeneration in the adult zebrafish kidney. Developmental Biology. 454(1):44-51
- Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Petit, D., Teppa, E., Mir, A., Vicogne, D., Thisse, C., Thisse, B., Filloux, C., Harduin-Lepers, A. (2015) Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage specific losses. Mol. Biol. Evol.. 32(4):906-27
- Wehner, D., Cizelsky, W., Vasudevaro, M.D., Özhan, G., Haase, C., Kagermeier-Schenk, B., Röder, A., Dorsky, R.I., Moro, E., Argenton, F., Kühl, M., and Weidinger, G. (2014) Wnt/β-Catenin Signaling Defines Organizing Centers that Orchestrate Growth and Differentiation of the Regenerating Zebrafish Caudal Fin. Cell Reports. 6(3):467-481
- Li, S., Lou, S., Lei, B.U., Chan, T.F., Kwan, Y.W., Chan, S.W., Leung, G.P., Tsui, S.K., and Lee, S.M. (2011) Transcriptional profiling of angiogenesis activities of calycosin in zebrafish. Molecular Biosystems. 7(11):3112-21
- Charoensawan, V., Adryan, B., Martin, S., Söllner, C., Thisse, B., Thisse, C., Wright, G.J., and Teichmann, S.A. (2010) The Impact of Gene Expression Regulation on Evolution of Extracellular Signaling Pathways. Molecular & cellular proteomics : MCP. 9(12):2666-2677
- Martin, S., Söllner, C., Charoensawan, V., Adryan, B., Thisse, B., Thisse, C., Teichmann, S.A., and Wright, G.J. (2010) Construction of a large extracellular protein interaction network and its resolution by spatiotemporal expression profiling. Molecular & cellular proteomics : MCP. 9(12):2654-2665
- Mueller, R.L., Huang, C., and Ho, R.K. (2010) Spatio-temporal regulation of Wnt and retinoic acid signaling by tbx16/spadetail during zebrafish mesoderm differentiation. BMC Genomics. 11:492
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