Gene
cdkn1ca
- ID
- ZDB-GENE-040123-1
- Name
- cyclin dependent kinase inhibitor 1Ca
- Symbol
- cdkn1ca Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity and kinase activity. Acts upstream of or within cell fate specification; glial cell differentiation; and negative regulation of mitotic cell cycle. Predicted to be located in nucleus. Is expressed in several structures, including mesoderm; muscle; nervous system; neural tube; and notochord. Human ortholog(s) of this gene implicated in Beckwith-Wiedemann syndrome; IMAGe syndrome; and hyperinsulinism. Orthologous to human CDKN1C (cyclin dependent kinase inhibitor 1C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 49 figures from 35 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb961 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Osborn et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa38636 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Beckwith-Wiedemann syndrome | Alliance | Beckwith-Wiedemann syndrome | 130650 |
| IMAGe syndrome | Alliance | IMAGE syndrome | 614732 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cyclin-dependent kinase inhibitor domain | Cyclin-dependent kinase inhibitor domain superfamily |
|---|---|---|---|
|
UniProtKB:Q6IQT7
|
212 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cdkn1ca-201
(1)
|
Ensembl | 1,566 nt | ||
| mRNA |
cdkn1ca-202
(1)
|
Ensembl | 1,953 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-7P8 | ZFIN Curated Data | |
| Encodes | EST | cb961 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:86618 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173881 | ZFIN Curated Data | |
| Is Hybridized by | STS | chunp487 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002040 (1) | 1199 nt | ||
| Genomic | GenBank:AL928843 (1) | 179577 nt | ||
| Polypeptide | UniProtKB:Q6IQT7 (1) | 212 aa |
- Lai, S., Shiraishi, H., Sebastian, W.A., Shimizu, N., Umeda, R., Ikeuchi, M., Kiyota, K., Takeno, T., Miyazaki, S., Yano, S., Shimada, T., Yoshimura, A., Hanada, R., Hanada, T. (2024) Effect of nonsense-mediated mRNA decay factor SMG9 deficiency on premature aging in zebrafish. Communications biology. 7:654654
- Wei, X., Tan, X., Chen, Q., Jiang, Y., Wu, G., Ma, X., Fu, J., Li, Y., Gang, K., Yang, Q., Ni, R., He, J., Luo, L. (2023) Extensive jejunal injury is repaired by migration and transdifferentiation of ileal enterocytes in zebrafish. Cell Reports. 42:112660112660
- Wu, C., Zhang, W., Luo, Y., Cheng, C., Wang, X., Jiang, Y., Li, S., Luo, L., Yang, Y. (2023) Zebrafish ppp1r21 mutant as a model for the study of primary biliary cholangitis. Journal of genetics and genomics = Yi chuan xue bao. 50(12):1004-1013
- Zhang, J., Li, P., Sun, L., Jiang, N., Guo, W., Wang, J., Gao, F., Li, J., Li, H., Zhang, J., Mu, H., Hu, Y., Cui, X. (2023) Knockout of miR-184 in zebrafish leads to ocular abnormalities by elevating p21 levels. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37:e22927e22927
- Schultz-Rogers, L.E., Thayer, M.L., Kambakam, S., Wierson, W.A., Helmer, J.A., Wishman, M.D., Wall, K.A., Greig, J.L., Forsman, J.L., Puchhalapalli, K., Nair, S., Weiss, T.J., Luiken, J.M., Blackburn, P.R., Ekker, S.C., Kool, M., McGrail, M. (2022) Rbbp4 loss disrupts neural progenitor cell cycle regulation independent of Rb and leads to Tp53 acetylation and apoptosis. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(8):1267-1290
- Zhang, J., Zhou, Y., Li, S., Mo, D., Ma, J., Ni, R., Yang, Q., He, J., Luo, L. (2022) Tel2 regulates redifferentiation of bipotential progenitor cells via Hhex during zebrafish liver regeneration. Cell Reports. 39:110596
- Hoffmann, S., Roeth, R., Diebold, S., Gogel, J., Hassel, D., Just, S., Rappold, G.A. (2021) Identification and Tissue-Specific Characterization of Novel SHOX-Regulated Genes in Zebrafish Highlights SOX Family Members Among Other Genes. Frontiers in genetics. 12:688808
- Li, X., Ji, G., Zhou, J., Du, J., Li, X., Shi, W., Hu, Y., Zhou, W., Hao, A. (2021) Pcgf1 Regulates Early Neural Tube Development Through Histone Methylation in Zebrafish. Frontiers in cell and developmental biology. 8:581636
- Yang, Y., Wang, H., He, J., Shi, W., Jiang, Z., Gao, L., Jiang, Y., Ni, R., Yang, Q., Luo, L. (2021) A single-cell-resolution fate map of endoderm reveals demarcation of pancreatic progenitors by cell cycle. Proceedings of the National Academy of Sciences of the United States of America. 118(25):
- Zhang, W., Wu, C., Ni, R., Yang, Q., Luo, L., He, J. (2021) Formimidoyltransferase cyclodeaminase prevents the starvation-induced liver hepatomegaly and dysfunction through downregulating mTORC1. PLoS Genetics. 17:e1009980
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