Gene
tal2
- ID
- ZDB-GENE-040115-1
- Name
- T-cell acute lymphocytic leukemia 2
- Symbol
- tal2 Nomenclature History
- Previous Names
-
- zgc:111884
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in brain development and ventral spinal cord interneuron differentiation. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia and adult T-cell leukemia. Is expressed in floor plate; neurons; and spinal cord. Orthologous to human TAL2 (TAL bHLH transcription factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Yang et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute lymphoblastic leukemia | Alliance | Leukemia, T-cell acute lymphocytic, somatic | 613065 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Helix-loop-helix DNA-binding domain superfamily | Helix-loop-helix protein TAL-like | Myc-type, basic helix-loop-helix (bHLH) domain |
|---|---|---|---|---|
|
UniProtKB:F1QUD8
|
109 |
Interactions and Pathways
No data available
Plasmids
No data available