Gene
hdac9b
- ID
- ZDB-GENE-040109-7
- Name
- histone deacetylase 9b
- Symbol
- hdac9b Nomenclature History
- Previous Names
-
- hdac9
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable NAD-dependent histone H3K14 deacetylase activity. Acts upstream of or within angiogenesis; lymph vessel development; and primitive erythrocyte differentiation. Predicted to be located in nucleus. Predicted to be part of histone deacetylase complex. Orthologous to human HDAC9 (histone deacetylase 9).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la019605Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la019607Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la019608Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa22811 | Allele with one point mutation | Unknown | Missense | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Auriculocondylar syndrome 4 | 620457 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR024643 | Histone deacetylase, glutamine rich N-terminal domain |
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Domain Details Per Protein
| Protein | Length | Histone deacetylase, glutamine rich N-terminal domain |
|---|---|---|
|
UniProtKB:Q6PBI4
|
582 | |
|
UniProtKB:A0A8M2B4U1
|
609 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hdac9b-201
(1)
|
Ensembl | 5,104 nt | ||
| mRNA |
hdac9b-202
(1)
|
Ensembl | 2,272 nt | ||
| mRNA |
hdac9b-206
(1)
|
Ensembl | 825 nt | ||
| ncRNA |
hdac9b-002
(1)
|
Ensembl | 3,778 nt | ||
| ncRNA |
hdac9b-004
(1)
|
Ensembl | 559 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-108F20 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-242C17 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:73392 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200816 (1) | 2181 nt | ||
| Genomic | GenBank:BX511151 | 157538 nt | ||
| Polypeptide | UniProtKB:A0A8M2B4U1 (1) | 609 aa |
- Yehuda, H., Madrer, N., Goldberg, D., Soreq, H., Meerson, A. (2023) Inversely Regulated Inflammation-Related Processes Mediate Anxiety-Obesity Links in Zebrafish Larvae and Adults. Cells. 12(13):
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Fellous, A., Earley, R.L., Silvestre, F. (2019) Identification and expression of mangrove rivulus (Kryptolebias marmoratus) histone deacetylase (Hdac) and lysine acetyltransferase (Kat) genes. Gene. 691:56-69
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Mitra, S., Sharma, P., Kaur, S., Khursheed, M.A., Gupta, S., Ahuja, R., Kurup, A.J., Chaudhary, M., Ramachandran, R. (2018) Histone Deacetylase-Mediated Müller Glia Reprogramming through Her4.1-Lin28a Axis Is Essential for Retina Regeneration in Zebrafish. iScience. 7:68-84
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- Kaluza, D., Kroll, J., Gesierich, S., Manavski, Y., Boeckel, J., Doebele, C., Zelent, A., Rossig, L., Zeiher, A. M., Augustin, H. G., Urbich, C., Dimmeler, S. (2013) Histone deacetylase 9 promotes angiogenesis by targeting the antiangiogenic microRNA-17-92 cluster in endothelial cells.. Arteriosclerosis, Thrombosis, and Vascular Biology. 33:533-543
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Birnbaum, R.Y., Clowney, E.J., Agamy, O., Kim, M.J., Zhao, J., Yamanaka, T., Pappalardo, Z., Clarke, S.L., Wenger, A.M., Nguyen, L., Gurrieri, F., Everman, D.B., Schwartz, C.E., Birk, O.S., Bejerano, G., Lomvardas, S., and Ahituv, N. (2012) Coding exons function as tissue-specific enhancers of nearby genes. Genome research. 22(6):1059-1068
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