Gene

chrna7a

ID

ZDB-GENE-040108-3

Name

cholinergic receptor, nicotinic, alpha 7a (neuronal)

Symbol

chrna7a Nomenclature History

Previous Names

chrna7

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Contributes to acetylcholine receptor activity. Involved in response to nicotine. Localizes to acetylcholine-gated channel complex. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With chrna7a Human Ortholog

No data available

Associated With chrna7a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018000	Neurotransmitter-gated ion-channel, conserved site
Domain	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
Domain	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain
Family	IPR002394	Nicotinic acetylcholine receptor
Family	IPR006201	Neurotransmitter-gated ion-channel
Homologous_superfamily	IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily
Homologous_superfamily	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Homologous_superfamily	IPR038050	Neuronal acetylcholine receptor

Domain Details Per Protein

Protein	Length	Neuronal acetylcholine receptor	Neurotransmitter-gated ion-channel	Neurotransmitter-gated ion-channel, conserved site	Neurotransmitter-gated ion-channel ligand-binding domain	Neurotransmitter-gated ion-channel ligand-binding domain superfamily	Neurotransmitter-gated ion-channel transmembrane domain	Neurotransmitter-gated ion-channel transmembrane domain superfamily	Nicotinic acetylcholine receptor
UniProtKB:Q800C7 InterPro	509

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	chrna7-201 (1) Ensembl	Ensembl	1,612 nt	Select Tool
mRNA	chrna7-202 (1) Ensembl	Ensembl	1,716 nt	Select Tool ZFIN BLAST
mRNA	ottdart00000002167 (1)	Havana	1,524 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations