Gene
jam2a
- ID
- ZDB-GENE-031204-3
- Name
- junctional adhesion molecule 2a
- Symbol
- jam2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Enables protein heterodimerization activity. Involved in regulation of skeletal muscle fiber development. Acts upstream of or within with a positive effect on myoblast fusion. Acts upstream of or within hematopoietic or lymphoid organ development. Predicted to be located in bicellular tight junction and membrane. Predicted to be part of protein complex involved in cell adhesion. Predicted to be active in cell surface; plasma membrane; and tight junction. Is expressed in several structures, including blood vessel; musculature system; myoblast; nervous system; and pectoral fin bud. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human JAM2 (junctional adhesion molecule 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1002 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Basal ganglia calcification, idiopathic, 8, autosomal recessive | 618824 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Immunoglobulin V-set domain | Junctional adhesion molecule B |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A4JYM3
|
307 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-41E3 | ZFIN Curated Data | |
| Encodes | EST | cb1002 | Thisse et al., 2001 | |
| Encodes | cDNA | cssl:d187 | Bushell et al., 2007 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001098264 (1) | 1236 nt | ||
| Genomic | GenBank:CU571081 (2) | 130071 nt | ||
| Polypeptide | UniProtKB:A4JYM3 (1) | 307 aa |
- Das, R.N., Tevet, Y., Safriel, S., Han, Y., Moshe, N., Lambiase, G., Bassi, I., Nicenboim, J., Brückner, M., Hirsch, D., Eilam-Altstadter, R., Herzog, W., Avraham, R., Poss, K.D., Yaniv, K. (2022) Generation of specialized blood vessels via lymphatic transdifferentiation. Nature. 606(7914):570-575
- Hayashiji, N., Kawahara, G., Xu, X., Fukuda, T., Kerever, A., Gu, J., Hayashi, Y.K., Arikawa-Hirasawa, E. (2022) α-1,6-Fucosyltransferase Is Essential for Myogenesis in Zebrafish. Cells. 12(1):
- Luo, Z., Shi, J., Pandey, P., Ruan, Z.R., Sevdali, M., Bu, Y., Lu, Y., Du, S., Chen, E.H. (2022) The cellular architecture and molecular determinants of the zebrafish fusogenic synapse. Developmental Cell. 57(13):1582-1597.e6
- Eom, D.S., Patterson, L.B., Bostic, R.R., Parichy, D.M. (2021) Immunoglobulin superfamily receptor junctional adhesion molecule 3 (Jam3) requirement for melanophore survival and patterning during formation of zebrafish stripes. Developmental Biology. 476:314-327
- Hromowyk, K.J., Talbot, J.C., Martin, B.L., Janssen, P.M.L., Amacher, S.L. (2020) Cell fusion is differentially regulated in zebrafish post-embryonic slow and fast muscle. Developmental Biology. 462(1):85-100
- Kobayashi, I., Kobayashi-Sun, J., Hirakawa, Y., Ouchi, M., Yasuda, K., Kamei, H., Fukuhara, S., Yamaguchi, M. (2019) Dual role of Jam3b in early hematopoietic and vascular development. Development (Cambridge, England). 147(1):
- Zhong, X., Kang, J., Qiu, J., Yang, W., Wu, J., Ji, D., Yu, Y., Ke, W., Shi, X., Wei, Y. (2019) Developmental exposure to BDE-99 hinders cerebrovascular growth and disturbs vascular barrier formation in zebrafish larvae. Aquatic toxicology (Amsterdam, Netherlands). 214:105224
- Bickers, C., Española, S.D., Grainger, S., Pouget, C., Traver, D. (2018) Zebrafish snai2 mutants fail to phenocopy morphant phenotypes. PLoS One. 13:e0202747
- Ganassi, M., Badodi, S., Ortuste Quiroga, H.P., Zammit, P.S., Hinits, Y., Hughes, S.M. (2018) Myogenin promotes myocyte fusion to balance fibre number and size. Nature communications. 9:4232
- Si, Y., Wen, H., Du, S. (2018) Genetic Mutations in jamb, jamc, and myomaker Revealed Different Roles on Myoblast Fusion and Muscle Growth. Marine biotechnology (New York, N.Y.). 21(1):111-123
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