Gene
lyve1a
- ID
- ZDB-GENE-031118-138
- Name
- lymphatic vessel endothelial hyaluronic receptor 1a
- Symbol
- lyve1a Nomenclature History
- Previous Names
-
- hm:zeh0104
- si:dkeyp-104h2.3
- zeh0104
- zmp:0000000782
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables hyaluronic acid binding activity. Acts upstream of or within lymphangiogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in posterior cardinal vein. Orthologous to human LYVE1 (lymphatic vessel endothelial hyaluronan receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Chen et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Chen et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa14763 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-lyve1a | N/A | Chen et al., 2013 |
| MO2-lyve1a | N/A | Chen et al., 2013 |
| MO3-lyve1a | N/A | Chen et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | CD44 antigen-like | C-type lectin fold | C-type lectin-like/link domain superfamily | Link domain |
|---|---|---|---|---|---|
|
UniProtKB:F1R2G7
|
328 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
lyve1a-201
(1)
|
Ensembl | 1,472 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-104H2 | ZFIN Curated Data | |
| Encodes | EST | zeh0104 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001309475 (1) | 1259 nt | ||
| Genomic | GenBank:CU468622 (1) | 166269 nt | ||
| Polypeptide | UniProtKB:F1R2G7 (1) | 328 aa |
- Comparative Orthology
- Alliance
- Tsaryk, R., Yucel, N., Leonard, E.V., Diaz, N., Bondareva, O., Odenthal-Schnittler, M., Arany, Z., Vaquerizas, J.M., Schnittler, H., Siekmann, A.F. (2022) Shear stress switches the association of endothelial enhancers from ETV/ETS to KLF transcription factor binding sites. Scientific Reports. 12:4795
- Wild, R., Klems, A., Takamiya, M., Hayashi, Y., Strähle, U., Ando, K., Mochizuki, N., van Impel, A., Schulte-Merker, S., Krueger, J., Preau, L., le Noble, F. (2017) Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization. Nature communications. 8:13991
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Chen, W., Tseng, X., Lin, G., Schreiner, A., Chen, H., Voigt, M.M., Yuh, C., Wu, J., Huang, S.S., and Huang, J. (2013) The Ortholog of LYVE-1 Is Required for Thoracic Duct Formation in Zebrafish. CellBio. 2(4):228-247
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