Gene
dnaaf1
- ID
- ZDB-GENE-031114-4
- Name
- dynein axonemal assembly factor 1
- Symbol
- dnaaf1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables dynein complex binding activity. Involved in cilium assembly. Acts upstream of or within several processes, including axoneme assembly; central canal development; and embryonic heart tube development. Predicted to be located in cilium. Predicted to be active in axoneme. Is expressed in several structures, including chordo neural hinge; forerunner cell group; intermediate mesoderm; nervous system; and pronephric duct. Used to study autosomal dominant polycystic kidney disease; idiopathic scoliosis; seminoma; and testicular germ cell cancer. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 13. Orthologous to human DNAAF1 (dynein axonemal assembly factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 30 figures from 15 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fk03a | Allele with one point mutation | Unknown | Premature Stop | not specified | |
| hu255H | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20957 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40903 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tm317b | Allele with one point mutation | Unknown | Missense | not specified | |
| zf3430 | unknown | Unknown | Unknown | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary ciliary dyskinesia 13 | Alliance | Ciliary dyskinesia, primary, 13 | 613193 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Ciliary and flagellar integrity-associated protein | Leucine-rich repeat | Leucine-rich repeat domain superfamily |
|---|---|---|---|---|
|
UniProtKB:F1Q654
|
562 | |||
|
UniProtKB:Q7ZV84
|
555 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
dnaaf1-202
(1)
|
Ensembl | 604 nt | ||
| mRNA |
dnaaf1-201
(1)
|
Ensembl | 2,594 nt | ||
| mRNA |
dnaaf1-203
(1)
|
Ensembl | 550 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-97H16 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56169 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001319131 (1) | 1944 nt | ||
| Genomic | GenBank:CR376738 (2) | 118757 nt | ||
| Polypeptide | UniProtKB:F1Q654 (1) | 562 aa |
- Kurup, A.J., Bailet, F., Fürthauer, M. (2024) Myosin1G promotes Nodal signaling to control zebrafish left-right asymmetry. Nature communications. 15:65476547
- Peng, L., Fu, W., Wu, X., He, S., Zhao, H., Liu, J., Liu, W., Xiao, Y. (2020) Bisexual Fertile Triploid Zebrafish (Danio rerio): a Rare Case. Marine biotechnology (New York, N.Y.). 22(3):443-455
- Thouvenin, O., Keiser, L., Cantaut-Belarif, Y., Carbo-Tano, M., Verweij, F., Jurisch-Yaksi, N., Bardet, P.L., van Niel, G., Gallaire, F., Wyart, C. (2020) Origin and role of the cerebrospinal fluid bidirectional flow in the central canal. eLIFE. 9:
- Wang, Y., Liu, Z., Yang, G., Gao, Q., Xiao, L., Li, J., Guo, C., Troutwine, B.R., Gray, R.S., Xie, L., Zhang, H. (2020) Coding Variants Coupled With Rapid Modeling in Zebrafish Implicate Dynein Genes, dnaaf1 and zmynd10, as Adolescent Idiopathic Scoliosis Candidate Genes. Frontiers in cell and developmental biology. 8:582255
- Whitfield, T.T. (2020) Cilia in the developing zebrafish ear. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 375:20190163
- Xie, H., Kang, Y., Wang, S., Zheng, P., Chen, Z., Roy, S., Zhao, C. (2020) E2f5 is a versatile transcriptional activator required for spermatogenesis and multiciliated cell differentiation in zebrafish. PLoS Genetics. 16:e1008655
- Ferreira, R.R., Pakula, G., Klaeyle, L., Fukui, H., Vilfan, A., Supatto, W., Vermot, J. (2018) Chiral Cilia Orientation in the Left-Right Organizer. Cell Reports. 25:2008-2016.e4
- Juan, T., Géminard, C., Coutelis, J.B., Cerezo, D., Polès, S., Noselli, S., Fürthauer, M. (2018) Myosin1D is an evolutionarily conserved regulator of animal left-right asymmetry. Nature communications. 9:1942
- Zhang, X., Jia, S., Chen, Z., Chong, Y.L., Xie, H., Feng, D., Wu, X., Song, D.Z., Roy, S., Zhao, C. (2018) Cilia-driven cerebrospinal fluid flow directs expression of urotensin neuropeptides to straighten the vertebrate body axis. Nature Genetics. 50(12):1666-1673
- Hartill, V.L., van de Hoek, G., Patel, M.P., Little, R., Watson, C.M., Berry, I.R., Shoemark, A., Abdelmottaleb, D., Parkes, E., Bacchelli, C., Szymanska, K., Knoers, N.V., Scambler, P.J., Ueffing, M., Boldt, K., Yates, R., Winyard, P.J., Adler, B., Moya, E., Hattingh, L., Shenoy, A., Hogg, C., Sheridan, E., Roepman, R., Norris, D., Mitchison, H.M., Giles, R.H., Johnson, C.A. (2017) DNAAF1 links heart laterality with the AAA+ ATPase RUVBL1 and ciliary intraflagellar transport. Human molecular genetics. 27(3):529-545
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