Gene
fen1
- ID
- ZDB-GENE-031112-11
- Name
- flap structure-specific endonuclease 1
- Symbol
- fen1 Nomenclature History
- Previous Names
-
- cb879 (1)
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity and nuclease activity. Acts upstream of or within retina development in camera-type eye. Predicted to be located in mitochondrion; nucleolus; and nucleoplasm. Predicted to be active in nucleus. Is expressed in brain; head; pectoral fin musculature; and proliferative region. Orthologous to human FEN1 (flap structure-specific endonuclease 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb879 (6 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi4026Tg | Transgenic insertion | Exon 3 | Unknown | DNA | |
| sa15638 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa24456 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32479 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37839 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | 5'-3' exonuclease, C-terminal domain superfamily | Flap endonuclease 1 | Helix-hairpin-helix motif, class 2 | PIN-like domain superfamily | XPG conserved site | XPG-I domain | XPG, N-terminal | XPG/Rad2 endonuclease |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6TNU4
|
380 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Encodes | EST | cb879 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:56370 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:86842 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_198820 (1) | 1657 nt | ||
| Genomic | GenBank:CABZ01101620 (1) | 12264 nt | ||
| Polypeptide | UniProtKB:Q6TNU4 (1) | 380 aa |