Gene
ddit4
- ID
- ZDB-GENE-031002-35
- Name
- DNA-damage-inducible transcript 4
- Symbol
- ddit4 Nomenclature History
- Previous Names
-
- redd1 (1)
- sb:cb821
- zgc:64114
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable 14-3-3 protein binding activity. Acts upstream of or within dorsal/ventral pattern formation. Predicted to be located in cytoplasm. Is expressed in several structures, including central nervous system; digestive system; mesoderm; muscle; and pleuroperitoneal region. Orthologous to human DDIT4 (DNA damage inducible transcript 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb821 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Feng et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | RTP801-like | RTP801-like, C-terminal domain superfamily |
|---|---|---|---|
|
UniProtKB:Q7T346
|
220 | ||
|
UniProtKB:H9LFU8
|
220 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-300E14 | ZFIN Curated Data | |
| Encodes | EST | cb821 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:64114 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200107 (1) | 1425 nt | ||
| Genomic | GenBank:FP102054 (1) | 96657 nt | ||
| Polypeptide | UniProtKB:H9LFU8 (1) | 220 aa |
- Yue, Y., Tang, Y., Huang, H., Zheng, D., Liu, C., Zhang, H., Liu, Y., Li, Y., Sun, X., Lu, L. (2023) VBP1 negatively regulates CHIP and selectively inhibits the activity of hypoxia-inducible factor (HIF)-1α but not HIF-2α. The Journal of biological chemistry. 299(6):104829
- Dinarello, A., Tesoriere, A., Martini, P., Fontana, C.M., Volpato, D., Badenetti, L., Terrin, F., Facchinello, N., Romualdi, C., Carnevali, O., Dalla Valle, L., Argenton, F. (2022) Zebrafish Mutant Lines Reveal the Interplay between nr3c1 and nr3c2 in the GC-Dependent Regulation of Gene Transcription. International Journal of Molecular Sciences. 23(5):
- Ding, Y., Wang, M., Bu, H., Li, J., Lin, X., Xu, X. (2022) An F0-based genetic assay in adult zebrafish for discovering modifier genes of an inherited cardiomyopathy. Disease models & mechanisms. 16(5):
- Faught, E., Vijayan, M.M. (2022) The mineralocorticoid receptor functions as a key glucose regulator in the skeletal muscle of zebrafish. Endocrinology. 163(11):
- Nipu, N., Antomagesh, F., Faught, E., Vijayan, M.M. (2022) Glucocorticoid receptor activation reduces food intake independent of hyperglycemia in zebrafish. Scientific Reports. 12:15677
- Wu, X., Chen, J., Liu, C., Wang, X., Zhou, H., Mai, K., He, G. (2022) Slc38a9 Deficiency Induces Apoptosis and Metabolic Dysregulation and Leads to Premature Death in Zebrafish. International Journal of Molecular Sciences. 23(8):
- Faught, E., Vijayan, M.M. (2019) Loss of the glucocorticoid receptor in zebrafish improves muscle glucose availability and increases growth. American journal of physiology. Endocrinology and metabolism. 316(6):E1093-E1104
- Faught, E., Vijayan, M.M. (2019) Glucocorticoid and mineralocorticoid receptor activation modulates postnatal growth. The Journal of endocrinology. 244(2):261-271
- Yang, Y., Dong, F., Liu, X., Xu, J., Wu, X., Wang, D., Zheng, Y. (2019) Developmental toxicity by thifluzamide in zebrafish (Danio rerio): Involvement of leptin. Chemosphere. 221:863-869
- Feng, N., Bian, Z., Zhang, X., Wang, C., Chen, J. (2018) Rapamycin reduces mortality in acute-stage paraquat-induced toxicity in zebrafish. Singapore medical journal. 60(5):241-246
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