Gene
g6pc1a.1
- ID
- ZDB-GENE-031001-4
- Name
- glucose-6-phosphatase catalytic subunit 1a, tandem duplicate 1
- Symbol
- g6pc1a.1 Nomenclature History
- Previous Names
-
- cb822 (1)
- g6pc
- g6pca.1
- g6pca
- zgc:92368
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable glucose-6-phosphatase activity. Predicted to be involved in gluconeogenesis and glucose 6-phosphate metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane. Is expressed in digestive system; liver; male organism; and yolk syncytial layer. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and type 2 diabetes mellitus. Orthologous to human G6PC1 (glucose-6-phosphatase catalytic subunit 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 18 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb822 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa35207 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| glycogen storage disease Ia | Alliance | Glycogen storage disease Ia | 232200 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Glucose-6-phosphatase | Phosphatidic acid phosphatase type 2/haloperoxidase | Phosphatidic acid phosphatase type 2/haloperoxidase superfamily |
|---|---|---|---|---|
|
UniProtKB:E7F5Z2
|
322 | |||
|
UniProtKB:A0A8M1N1J9
|
352 | |||
|
UniProtKB:A0A8M6Z3H1
|
203 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
g6pca.1-201
(1)
|
Ensembl | 1,266 nt | ||
| mRNA |
g6pca.1-202
(1)
|
Ensembl | 525 nt | ||
| mRNA |
g6pca.1-203
(1)
|
Ensembl | 1,298 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-131K2 | ZFIN Curated Data | |
| Contained in | BAC | CH211-215L11 | ZFIN Curated Data | |
| Encodes | EST | cb822 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:92368 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191336 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003512 (1) | 1310 nt | ||
| Genomic | GenBank:BX248126 (1) | 193490 nt | ||
| Polypeptide | UniProtKB:A0A8M1N1J9 (1) | 352 aa |
- Chen, J., Ji, X., Gao, J., Huang, J., Ren, J. (2024) gys1 regulates maternal glycogen reserve essential for embryonic development in zebrafish. Heliyon. 10:e31149e31149
- Chen, J., Zhao, W., Cao, L., Martins, R.S.T., Canário, A.V.M. (2024) Somatostatin signalling coordinates energy metabolism allocation to reproduction in zebrafish. BMC Biology. 22:163163
- Du, Q., Shao, R., Wang, W., Zhang, H., Liao, X., Wang, Z., Yin, Z., Ai, Q., Mai, K., Tang, X., Wan, M. (2024) Vitamin D3 Regulates Energy Homeostasis under Short-Term Fasting Condition in Zebrafish (Danio Rerio). Nutrients. 16(9):
- Prykhozhij, S.V., Ban, K., Brown, Z.L., Kobar, K., Wajnberg, G., Fuller, C., Chacko, S., Lacroix, J., Crapoulet, N., Midgen, C., Shlien, A., Malkin, D., Berman, J.N. (2024) miR-34a is a tumor suppressor in zebrafish and its expression levels impact metabolism, hematopoiesis and DNA damage. PLoS Genetics. 20:e1011290e1011290
- Ulhaq, Z.S., Tse, W.K.F. (2024) PFHxS Exposure and the Risk of Non-Alcoholic Fatty Liver Disease. Genes. 15(1):
- Liu, R., Lu, Y., Peng, X., Jia, J., Ruan, Y., Shi, S., Shu, T., Li, T., Jin, X., Zhai, G., He, J., Lou, Q., Yin, Z. (2023) Enhanced insulin activity achieved in VDRa/b ablation zebrafish. Frontiers in endocrinology. 14:10546651054665
- Xi, L., Lu, Q., Liu, Y., Gong, Y., Liu, H., Jin, J., Zhang, Z., Yang, Y., Zhu, X., Han, D., Xie, S. (2023) Study on Carbohydrate Metabolism in Adult Zebrafish (Danio rerio). Aquaculture nutrition. 2023:13975081397508
- Shao, R., Liao, X., Lan, Y., Zhang, H., Jiao, L., Du, Q., Han, D., Ai, Q., Mai, K., Wan, M. (2022) Vitamin D regulates insulin pathway and glucose metabolism in zebrafish (Danio rerio). FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36:e22330
- Tabler, C.T., Lodd, E., Bennewitz, K., Middel, C.S., Erben, V., Ott, H., Poth, T., Fleming, T., Morgenstern, J., Hausser, I., Sticht, C., Poschet, G., Szendroedi, J., Nawroth, P.P., Kroll, J. (2022) Loss of glyoxalase 2 alters the glucose metabolism in zebrafish. Redox Biology. 59:102576102576
- Wohlfart, D.P., Lou, B., Middel, C.S., Morgenstern, J., Fleming, T., Sticht, C., Hausser, I., Hell, R., Hammes, H.P., Szendrödi, J., Nawroth, P.P., Kroll, J. (2022) Accumulation of acetaldehyde in aldh2.1-/- zebrafish causes increased retinal angiogenesis and impaired glucose metabolism. Redox Biology. 50:102249
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