Gene

atrx

ID

ZDB-GENE-030912-11

Name

ATRX chromatin remodeler

Symbol

atrx Nomenclature History

Previous Names

wu:fb26e12
wu:fb52h08
wu:fb72g09

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to enable chromatin DNA binding activity. Predicted to be involved in positive regulation of telomeric RNA transcription from RNA pol II promoter and replication fork processing. Predicted to act upstream of or within DNA repair. Predicted to be located in chromosome, telomeric region and nucleus. Used to study alpha thalassemia-X-linked intellectual disability syndrome. Human ortholog(s) of this gene implicated in X-linked mental retardation-hypotonic facies syndrome-1; alpha thalassemia-X-linked intellectual disability syndrome; alpha-thalassemia myelodysplasia syndrome; high grade glioma; and lung small cell carcinoma. Orthologous to human ATRX (ATRX chromatin remodeler).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:66223 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Oppel et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With atrx Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
alpha thalassemia-X-linked intellectual disability syndrome	Alliance	Alpha-thalassemia/impaired intellectual development syndrome	301040
alpha-thalassemia myelodysplasia syndrome	Alliance	Alpha-thalassemia myelodysplasia syndrome, somatic	300448
		Intellectual disability-hypotonic facies syndrome, X-linked	309580

Associated With atrx Via Experimental Models

Human Disease	Fish	Conditions	Citations
alpha thalassemia-X-linked intellectual disability syndrome	atrx^zdf36/zdf36 (AB)	standard conditions	Oppel et al., 2019

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000330	SNF2, N-terminal
Domain	IPR001650	Helicase, C-terminal domain-like
Domain	IPR014001	Helicase superfamily 1/2, ATP-binding domain
Domain	IPR025766	ADD domain
Domain	IPR041430	ATRX, ADD domain
Domain	IPR049730	SNF2/RAD5-like, C-terminal helicase domain
Family	IPR052131	ATRX domain-containing protein
Homologous_superfamily	IPR011011	Zinc finger, FYVE/PHD-type
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR038718	SNF2-like, N-terminal domain superfamily

Domain Details Per Protein

Protein	Length	ADD domain	ATRX, ADD domain	ATRX domain-containing protein	Helicase, C-terminal domain-like	Helicase superfamily 1/2, ATP-binding domain	P-loop containing nucleoside triphosphate hydrolase	SNF2-like, N-terminal domain superfamily	SNF2, N-terminal	SNF2/RAD5-like, C-terminal helicase domain	Zinc finger, FYVE/PHD-type	Zinc finger, RING/FYVE/PHD-type
UniProtKB:A0A8M9QKH6 InterPro	2053
UniProtKB:E7F4M2 InterPro	2013

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	atrx-201 (1) Ensembl	Ensembl	8,416 nt	Select Tool ZFIN BLAST
mRNA	atrx-202 (1) Ensembl	Ensembl	7,483 nt	Select Tool ZFIN BLAST
ncRNA	atrx-002 (1) Ensembl	Ensembl	581 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations