Gene

mcm6

ID

ZDB-GENE-030909-6

Name

minichromosome maintenance complex component 6

Symbol

mcm6 Nomenclature History

Previous Names

MCM6z (1)
cb800 (1)
im:7140796
wu:fb30d05
wu:fc26f09

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to contribute to single-stranded 3'-5' DNA helicase activity. Predicted to be involved in DNA-dependent DNA replication and double-strand break repair via break-induced replication. Predicted to localize to MCM complex and nucleus. Is expressed in central nervous system and proliferative region. Orthologous to human MCM6 (minichromosome maintenance complex component 6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

16 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb800 (6 images)
IMAGE:7140796 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mcm6 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
lactose intolerance	Alliance	Lactase persistence/nonpersistence	223100

Associated With mcm6 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018525	Mini-chromosome maintenance, conserved site
Domain	IPR001208	MCM domain
Domain	IPR027925	MCM, N-terminal domain
Domain	IPR033762	MCM OB domain
Domain	IPR041024	Mcm6, C-terminal winged-helix domain
Domain	IPR041562	MCM, AAA-lid domain
Family	IPR008049	DNA replication licensing factor Mcm6
Family	IPR031327	Mini-chromosome maintenance protein
Homologous_superfamily	IPR012340	Nucleic acid-binding, OB-fold
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase