Gene
mcm6
- ID
- ZDB-GENE-030909-6
- Name
- minichromosome maintenance complex component 6
- Symbol
- mcm6 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable single-stranded DNA binding activity. Predicted to contribute to single-stranded 3'-5' DNA helicase activity. Predicted to be involved in DNA unwinding involved in DNA replication; double-strand break repair via break-induced replication; and mitotic DNA replication. Predicted to act upstream of or within DNA duplex unwinding and DNA replication initiation. Predicted to be part of MCM complex. Predicted to be active in nucleus. Is expressed in central nervous system and proliferative region. Orthologous to human MCM6 (minichromosome maintenance complex component 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb800 (6 images)
- IMAGE:7140796 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| lactose intolerance | Alliance | Lactase persistence/nonpersistence | 223100 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018525 | Mini-chromosome maintenance, conserved site |
| Domain | IPR001208 | MCM domain |
| Domain | IPR027925 | MCM, N-terminal domain |
| Domain | IPR033762 | MCM OB domain |
| Domain | IPR041024 | Mcm6, C-terminal winged-helix domain |
| Domain | IPR041562 | MCM, AAA-lid domain |
| Family | IPR008049 | DNA replication licensing factor Mcm6 |
| Family | IPR031327 | Mini-chromosome maintenance protein |
| Homologous_superfamily | IPR012340 | Nucleic acid-binding, OB-fold |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | DNA replication licensing factor Mcm6 | Mcm6, C-terminal winged-helix domain | MCM, AAA-lid domain | MCM domain | MCM, N-terminal domain | MCM OB domain | Mini-chromosome maintenance, conserved site | Mini-chromosome maintenance protein | Nucleic acid-binding, OB-fold | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A3KMS0
|
830 |
Interactions and Pathways
No data available
Plasmids
No data available