Gene
cadps2
- ID
- ZDB-GENE-030903-1
- Name
- Ca++-dependent secretion activator 2
- Symbol
- cadps2 Nomenclature History
- Previous Names
-
- cpd2 (1)
- zgc:110135
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity. Predicted to act upstream of or within dense core granule exocytosis and synaptic vesicle exocytosis. Is expressed in hatching gland; nervous system; otic vesicle; pronephric duct; and trigeminal placode. Orthologous to human CADPS2 (calcium dependent secretion activator 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110135 (12 images)
- eu166 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la014721Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la014722Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la023268Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la023271Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa6001 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa12715 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24694 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24695 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa24696 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa25229 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | C2 domain | Calcium-dependent secretion activator | Munc13 homology 1 | MUN domain |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PTA0
|
483 | ||||
|
UniProtKB:F1RCG6
|
396 | ||||
|
UniProtKB:A0A8M9PVK9
|
1128 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
cadps2-203
(1)
|
Ensembl | 539 nt | ||
| mRNA |
cadps2-201
(1)
|
Ensembl | 1,618 nt | ||
| mRNA |
cadps2-202
(1)
|
Ensembl | 2,572 nt | ||
| mRNA |
cadps2-204
(1)
|
Ensembl | 769 nt | ||
| mRNA |
cadps2-205
(1)
|
Ensembl | 1,811 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-71G21 | ZFIN Curated Data | |
| Contained in | BAC | CH211-142M8 | ZFIN Curated Data | |
| Contained in | BAC | CH211-245M13 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-1P18 | ZFIN Curated Data | |
| Encodes | EST | eu166 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:110135 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020491 (1) | 1649 nt | ||
| Genomic | GenBank:CR752641 (1) | 238675 nt | ||
| Polypeptide | UniProtKB:A0A8M9PVK9 (1) | 1128 aa |
- Wang, G.T., Pan, H.Y., Lang, W.H., Yu, Y.D., Hsieh, C.H., Kuan, Y.S. (2021) Three-dimensional multi-gene expression maps reveal cell fate changes associated with laterality reversal of zebrafish habenula. Journal of neuroscience research. 99(6):1632-1645
- Weger, M., Diotel, N., Weger, B.D., Beil, T., Zaucker, A., Eachus, H.L., Oakes, J.A., do Rego, J.L., Storbeck, K.H., Gut, P., Straehle, U., Rastegar, S., Mueller, F., Krone, N. (2018) Expression and activity profiling of the steroidogenic enzymes of glucocorticoid biosynthesis and the fdx1 co-factors in zebrafish. Journal of neuroendocrinology. 30(4):e12586
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Dean, B.J., Erdogan, B., Gamse, J.T., Wu, S.Y. (2014) Dbx1b defines the dorsal habenular progenitor domain in the zebrafish epithalamus. Neural Development. 9:20
- Hüsken, U., Stickney, H.L., Gestri, G., Bianco, I.H., Faro, A., Young, R.M., Roussigne, M., Hawkins, T.A., Beretta, C.A., Brinkmann, I., Paolini, A., Jacinto, R., Albadri, S., Dreosti, E., Tsalavouta, M., Schwarz, Q., Cavodeassi, F., Barth, A.K., Wen, L., Zhang, B., Blader, P., Yaksi, E., Poggi, L., Zigman, M., Lin, S., Wilson, S.W., Carl, M. (2014) Tcf7l2 Is Required for Left-Right Asymmetric Differentiation of Habenular Neurons. Current biology : CB. 24(19):2217-27
- Wu, S.Y., de Borsetti, N.H., Bain, E.J., Bulow, C.R., and Gamse, J.T. (2014) Mediator subunit 12 coordinates intrinsic and extrinsic control of epithalamic development. Developmental Biology. 385(1):13-22
- Colombo, A., Palma, K., Armijo, L., Mione, M., Signore, I.A., Morales, C., Guerrero, N., Meynard, M.M., Pérez, R., Suazo, J., Marcelain, K., Briones, L., Härtel, S., Wilson, S.W., and Concha, M.L. (2013) Daam1a mediates asymmetric habenular morphogenesis by regulating dendritic and axonal outgrowth. Development (Cambridge, England). 140(19):3997-4007
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- de Borsetti, N.H., Dean, B.J., Bain, E.J., Clanton, J.A., Taylor, R.W., and Gamse, J.T. (2011) Light and melatonin schedule neuronal differentiation in the habenular nuclei. Developmental Biology. 358(1):251-61
- Matos-Cruz, V., Blasic, J., Nickle, B., Robinson, P.R., Hattar, S., and Halpern, M.E. (2011) Unexpected diversity and photoperiod dependence of the zebrafish melanopsin system. PLoS One. 6(9):e25111
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