Gene

plaa

ID

ZDB-GENE-030826-13

Name

phospholipase A2-activating protein

Symbol

plaa Nomenclature History

Previous Names

cb623 (1)
wu:fc45d08
wu:fi33e06
zgc:56568
zgc:66193

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have ubiquitin binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and ubiquitin recycling. Predicted to localize to cytoplasm and nucleus. Is expressed in several structures, including eye; ovary; pectoral fin musculature; solid lens vesicle; and trigeminal placode. Orthologous to human PLAA (phospholipase A2 activating protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb623 (9 images)
IMAGE:7158753 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With plaa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies	617527

Associated With plaa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR013535	PUL domain
Domain	IPR015155	PLAA family ubiquitin binding domain
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Homologous_superfamily	IPR038122	PFU domain superfamily
Repeat	IPR001680	WD40 repeat