Gene

kif1b

ID

ZDB-GENE-030820-1

Name

kinesin family member 1B

Symbol

kif1b Nomenclature History

Previous Names

unm st43
unm_st43
wu:fb74c11

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have ATP-dependent microtubule motor activity, plus-end-directed and microtubule binding activity. Involved in several processes, including axon extension; neuron projection maintenance; and posterior lateral line system development. Predicted to localize to axon; dendrite; and microtubule cytoskeleton. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2A1; carcinoma (multiple); multiple sclerosis; neuroblastoma; and pheochromocytoma. Is expressed in nervous system and neurons. Orthologous to human KIF1B (kinesin family member 1B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 11 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kif1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Charcot-Marie-Tooth disease type 2A1	Alliance	Charcot-Marie-Tooth disease, type 2A1	118210
		{Neuroblastoma, susceptibility to, 1}	256700

Associated With kif1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019821	Kinesin motor domain, conserved site
Domain	IPR000253	Forkhead-associated (FHA) domain
Domain	IPR001752	Kinesin motor domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR022140	Kinesin-like KIF1-type
Domain	IPR022164	Kinesin-like
Domain	IPR032405	Kinesin-associated
Domain	IPR049780	Kinesin-like protein KIF1A/B, pleckstrin homology domain
Homologous_superfamily	IPR008984	SMAD/FHA domain superfamily
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily

Domain Details Per Protein

Protein	Length	Forkhead-associated (FHA) domain	Kinesin-associated	Kinesin-like	Kinesin-like KIF1-type	Kinesin-like protein KIF1A/B, pleckstrin homology domain	Kinesin motor domain	Kinesin motor domain, conserved site	Kinesin motor domain superfamily	PH-like domain superfamily	Pleckstrin homology domain	P-loop containing nucleoside triphosphate hydrolase	SMAD/FHA domain superfamily
UniProtKB:A0A8M9PKM3 InterPro	1795
UniProtKB:A0A8M3AMT9 InterPro	1918
UniProtKB:A0A8M3AMV0 InterPro	1232
UniProtKB:A0A8M3ANK4 InterPro	1848
UniProtKB:A0A8M3AMU4 InterPro	1882
UniProtKB:F1QJ64 InterPro	1161
UniProtKB:A0A8M3ANK1 InterPro	1910
UniProtKB:A0A8M3AVA2 InterPro	1809
UniProtKB:A0A8M3AMU7 InterPro	1783
UniProtKB:A0A8M3B624 InterPro	1857
UniProtKB:A0A8M3AYC4 InterPro	1761
UniProtKB:F1QBV5 InterPro	1770
UniProtKB:A0A8M3B629 InterPro	1769
UniProtKB:A0A8M3AYB6 InterPro	1901
UniProtKB:A0A8M9PEY4 InterPro	1913
UniProtKB:A0A8M6Z4D8 InterPro	1798
UniProtKB:A0A8M2B951 InterPro	1147
UniProtKB:A0A8M3AV93 InterPro	1924
UniProtKB:A0A8M3B621 InterPro	1915
UniProtKB:A0A8M3AYB9 InterPro	1840
UniProtKB:E9QDE5 InterPro	1763
UniProtKB:A0A8M3AVA7 InterPro	1679
UniProtKB:A0A8M3AV98 InterPro	1887
UniProtKB:A0A8M3ANL2 InterPro	1685

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	kif1b-201 (1) Ensembl	Ensembl	8,275 nt	Select Tool ZFIN BLAST
mRNA	kif1b-202 (1) Ensembl	Ensembl	3,741 nt	Select Tool ZFIN BLAST
mRNA	kif1b-203 (1) Ensembl	Ensembl	8,161 nt	Select Tool
mRNA	kif1b-204 (1) Ensembl	Ensembl	4,012 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations