Gene
tgfb3
- ID
- ZDB-GENE-030723-4
- Name
- transforming growth factor, beta 3
- Symbol
- tgfb3 Nomenclature History
- Previous Names
-
- tgf beta 3 (1)
- wu:fc78g09
- zgc:92058
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity; type II transforming growth factor beta receptor binding activity; and type III transforming growth factor beta receptor binding activity. Acts upstream of or within hematopoietic stem cell differentiation; regulation of cartilage development; and regulation of ossification. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including cardiovascular system; fin; head; immature eye; and nervous system. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 5; arrhythmogenic right ventricular cardiomyopathy; and arrhythmogenic right ventricular dysplasia 1. Orthologous to human TGFB3 (transforming growth factor beta 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 47 figures from 28 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7150374 (11 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hu3526 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| mi49 | Allele with one delins | Unknown | Unknown | CRISPR | |
| sa1467 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36544 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| ue111 | Allele with one delins | Unknown | Unknown | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| arrhythmogenic right ventricular dysplasia 1 | Alliance | Arrhythmogenic right ventricular dysplasia 1 | 107970 |
| Loeys-Dietz syndrome 5 | Alliance | Loeys-Dietz syndrome 5 | 615582 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017948 | Transforming growth factor beta, conserved site |
| Domain | IPR001111 | TGF-beta, propeptide |
| Domain | IPR001839 | Transforming growth factor-beta, C-terminal |
| Family | IPR015615 | Transforming growth factor-beta-related |
| Family | IPR015618 | Transforming growth factor beta-3 |
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Domain Details Per Protein
| Protein | Length | Cystine-knot cytokine | TGF-beta, propeptide | Transforming growth factor-beta | Transforming growth factor beta-3 | Transforming growth factor beta, conserved site | Transforming growth factor-beta, C-terminal | Transforming growth factor-beta-related |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q66I23
|
410 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:tgfb3) |
|
| 1 | Lee et al., 2020 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-60D15 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-297M1 | ZFIN Curated Data | |
| Encodes | EST | fc78g09 | Cheah et al., 2005 | |
| Encodes | EST | IMAGE:7150374 | Thisse et al., 2004 | |
| Encodes | EST | tgf_beta_3 | Chen et al., 2003 | |
| Encodes | cDNA | MGC:92058 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_194386 (1) | 2035 nt | ||
| Genomic | GenBank:FP325132 (2) | 35292 nt | ||
| Polypeptide | UniProtKB:Q66I23 (1) | 410 aa |
- Brenet, A., Somkhit, J., Csaba, Z., Ciura, S., Kabashi, E., Yanicostas, C., Soussi-Yanicostas, N. (2024) Microglia Mitigate Neuronal Activation in a Zebrafish Model of Dravet Syndrome. Cells. 13(8):
- Raterman, S.T., Von Den Hoff, J.W., Dijkstra, S., De Vriend, C., Te Morsche, T., Broekman, S., Zethof, J., De Vrieze, E., Wagener, F.A.D.T.G., Metz, J.R. (2023) Disruption of the foxe1 gene in zebrafish reveals conserved functions in development of the craniofacial skeleton and the thyroid. Frontiers in cell and developmental biology. 11:11438441143844
- Rawling, M., Schiavone, M., Mugnier, A., Leclercq, E., Merrifield, D., Foey, A., Apper, E. (2023) Modulation of Zebrafish (Danio rerio) Intestinal Mucosal Barrier Function Fed Different Postbiotics and a Probiotic from Lactobacilli. Microorganisms. 11(12):
- Kumar, J., Kumar, M., Sharma, S., Srivastava, N., Singh, R., Hussain, M.A., Mazumder, S. (2022) Th1-Th2 and M1-M2 interplay sculpt Aeromonas hydrophila pathogenesis in zebrafish (Danio rerio). Fish & shellfish immunology. 127:357-365
- Rayrikar, A.Y., Wagh, G.A., Santra, M., Patra, C. (2022) Ccn2a-FGFR1-SHH signaling is necessary for intervertebral disc homeostasis and regeneration in adult zebrafish. Development (Cambridge, England). 150(1):
- Adachi, Y., Higuchi, A., Wakai, E., Shiromizu, T., Koiwa, J., Nishimura, Y. (2021) Involvement of homeobox transcription factor Mohawk in palatogenesis. Congenital anomalies. 62(1):27-37
- Grivas, D., González-Rajal, Á., de la Pompa, J.L. (2021) Midkine-a Regulates the Formation of a Fibrotic Scar During Zebrafish Heart Regeneration. Frontiers in cell and developmental biology. 9:669439
- Keatinge, M., Tsarouchas, T.M., Munir, T., Porter, N.J., Larraz, J., Gianni, D., Tsai, H.H., Becker, C.G., Lyons, D.A., Becker, T. (2021) CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury. PLoS Genetics. 17:e1009515
- Miklas, J.W., Levy, S., Hofsteen, P., Mex, D.I., Clark, E., Muster, J., Robitaille, A.M., Sivaram, G., Abell, L., Goodson, J.M., Pranoto, I., Madan, A., Chin, M.T., Tian, R., Murry, C.E., Moon, R.T., Wang, Y., Ruohola-Baker, H. (2021) Amino acid primed mTOR activity is essential for heart regeneration. iScience. 25:103574
- Molina-Villa, T., Ramírez-Vidal, L., Mendoza, V., Escalante-Alcalde, D., López-Casillas, F. (2021) Chordacentrum mineralization is delayed in zebrafish betaglycan-null mutants. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(1):213-225
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