Gene
slit1b
- ID
- ZDB-GENE-030722-4
- Name
- slit homolog 1b (Drosophila)
- Symbol
- slit1b Nomenclature History
- Previous Names
-
- chunp9742
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Acts upstream of or within cranial nerve morphogenesis. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. Is expressed in central nervous system; forebrain; hindbrain; hindbrain nucleus; and retinal inner nuclear layer. Orthologous to human SLIT1 (slit guidance ligand 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Zecca et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa6715 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa24209 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa37562 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa37563 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa43879 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43880 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa45778 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR013032 | EGF-like, conserved site |
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000372 | Leucine-rich repeat N-terminal domain |
| Domain | IPR000483 | Cysteine-rich flanking region, C-terminal |
| Domain | IPR000742 | EGF-like domain |
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Domain Details Per Protein
| Protein | Length | Concanavalin A-like lectin/glucanase domain superfamily | Cysteine-rich flanking region, C-terminal | Cystine knot, C-terminal | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | Laminin G domain | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat N-terminal domain | Leucine-rich repeat, typical subtype | Notch and Slit guidance protein |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q3Y6S4
|
1532 | |||||||||||||||
|
UniProtKB:A0A0R4IU60
|
1531 | |||||||||||||||
|
UniProtKB:A0A8M9PRT4
|
1241 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slit1b-201
(1)
|
Ensembl | 2,468 nt | ||
| mRNA |
slit1b-202
(1)
|
Ensembl | 1,919 nt | ||
| mRNA |
slit1b-203
(1)
|
Ensembl | 4,839 nt | ||
| mRNA |
slit1b-204
(1)
|
Ensembl | 5,117 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-389O21 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-208I21 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-347B23 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195126 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001034975 (1) | 5143 nt | ||
| Genomic | GenBank:CU855898 (2) | 85809 nt | ||
| Polypeptide | UniProtKB:Q3Y6S4 (1) | 1532 aa |
- Takeuchi, M., Yamaguchi, S., Yonemura, S., Kakiguchi, K., Sato, Y., Higashiyama, T., Shimizu, T., Hibi, M. (2015) Type IV Collagen Controls the Axogenesis of Cerebellar Granule Cells by Regulating Basement Membrane Integrity in Zebrafish. PLoS Genetics. 11:e1005587
- Zecca, A., Dyballa, S., Voltes, A., Bradley, R., Pujades, C. (2015) The Order and Place of Neuronal Differentiation Establish the Topography of Sensory Projections and the Entry Points within the Hindbrain. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:7475-86
- Schweitzer, J., Löhr, H., Bonkowsky, J.L., Hübscher, K., and Driever, W. (2013) Sim1a and Arnt2 contribute to hypothalamo-spinal axon guidance by regulating Robo2 activity via a Robo3-dependent mechanism. Development (Cambridge, England). 140(1):93-106
- Pan, Y.A., Choy, M., Prober, D.A., and Schier, A.F. (2012) Robo2 determines subtype-specific axonal projections of trigeminal sensory neurons. Development (Cambridge, England). 139(3):591-600
- Wong, G.K., Baudet, M.L., Norden, C., Leung, L., and Harris, W.A. (2012) Slit1b-robo3 signaling and N-cadherin regulate apical process retraction in developing retinal ganglion cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(1):223-2238
- Zhang, C., Gao, J., Zhang, H., Sun, L., and Peng, G. (2012) Robo2-Slit and Dcc-Netrin1 Coordinate Neuron Axonal Pathfinding within the Embryonic Axon Tracts. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(36):12589-12602
- Charoensawan, V., Adryan, B., Martin, S., Söllner, C., Thisse, B., Thisse, C., Wright, G.J., and Teichmann, S.A. (2010) The Impact of Gene Expression Regulation on Evolution of Extracellular Signaling Pathways. Molecular & cellular proteomics : MCP. 9(12):2666-2677
- Martin, S., Söllner, C., Charoensawan, V., Adryan, B., Thisse, B., Thisse, C., Teichmann, S.A., and Wright, G.J. (2010) Construction of a large extracellular protein interaction network and its resolution by spatiotemporal expression profiling. Molecular & cellular proteomics : MCP. 9(12):2654-2665
- Wyatt, C., Ebert, A., Reimer, M.M., Rasband, K., Hardy, M., Chien, C.B., Becker, T., and Becker, C.G. (2010) Analysis of the astray/robo2 Zebrafish Mutant Reveals that Degenerating Tracts Do Not Provide Strong Guidance Cues for Regenerating Optic Axons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(41):13838-13849
- Kastenhuber, E., Kern U., Bonkowsky, J.L., Chien, C.B., Driever, W., and Schweitzer, J. (2009) Netrin-DCC, Robo-Slit, and heparan sulfate proteoglycans coordinate lateral positioning of longitudinal dopaminergic diencephalospinal axons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(28):8914-8926
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