Gene
slit1b
- ID
- ZDB-GENE-030722-4
- Name
- slit homolog 1b (Drosophila)
- Symbol
- slit1b Nomenclature History
- Previous Names
-
- chunp9742
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Acts upstream of or within cranial nerve morphogenesis. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. Is expressed in central nervous system; forebrain; hindbrain; hindbrain nucleus; and retinal inner nuclear layer. Orthologous to human SLIT1 (slit guidance ligand 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Zecca et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR013032 | EGF-like, conserved site |
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000372 | Leucine-rich repeat N-terminal domain |
| Domain | IPR000483 | Cysteine-rich flanking region, C-terminal |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001791 | Laminin G domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR006207 | Cystine knot, C-terminal |
| Family | IPR051355 | Notch and Slit guidance protein |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
| Repeat | IPR001611 | Leucine-rich repeat |
| Repeat | IPR003591 | Leucine-rich repeat, typical subtype |
Domain Details Per Protein
| Protein | Length | Concanavalin A-like lectin/glucanase domain superfamily | Cysteine-rich flanking region, C-terminal | Cystine knot, C-terminal | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | Laminin G domain | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat N-terminal domain | Leucine-rich repeat, typical subtype | Notch and Slit guidance protein |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q3Y6S4
|
1532 | |||||||||||||||
|
UniProtKB:A0A0R4IU60
|
1531 | |||||||||||||||
|
UniProtKB:A0A8M9PRT4
|
1241 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slit1b-201
(1)
|
Ensembl | 2,468 nt | ||
| mRNA |
slit1b-202
(1)
|
Ensembl | 1,919 nt | ||
| mRNA |
slit1b-203
(1)
|
Ensembl | 4,839 nt | ||
| mRNA |
slit1b-204
(1)
|
Ensembl | 5,117 nt |
Interactions and Pathways
No data available
Plasmids