Gene

serpind1

ID

ZDB-GENE-030711-2

Name

serpin peptidase inhibitor, clade D (heparin cofactor), member 1

Symbol

serpind1 Nomenclature History

Previous Names

HCII (1)

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in thrombophilia. Is expressed in liver. Orthologous to human SERPIND1 (serpin family D member 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Cheng et al., 2006

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With serpind1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
heparin cofactor II deficiency	Alliance	Thrombophilia 10 due to heparin cofactor II deficiency	612356

Associated With serpind1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023795	Serpin, conserved site
Domain	IPR023796	Serpin domain
Domain	IPR033831	Heparin cofactor II, serpin domain
Family	IPR000215	Serpin family
Homologous_superfamily	IPR036186	Serpin superfamily
Homologous_superfamily	IPR042178	Serpin superfamily, domain 1
Homologous_superfamily	IPR042185	Serpin superfamily, domain 2