Gene
ctsc
- ID
- ZDB-GENE-030619-9
- Name
- cathepsin C
- Symbol
- ctsc Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to have cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in cellular protein catabolic process. Predicted to localize to extracellular space and lysosome. Is expressed in macrophage; neural crest; polster; somite; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Papillon-Lefevre disease and aggressive periodontitis. Orthologous to human CTSC (cathepsin C).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 14 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb146 (4 images)
- cb912 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
aggressive periodontitis | Alliance | Periodontitis 1, juvenile | 170650 |
Papillon-Lefevre disease | Alliance | Papillon-Lefevre syndrome | 245000 |
Haim-Munk syndrome | 245010 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR000169 | Cysteine peptidase, cysteine active site |
Active_site | IPR025660 | Cysteine peptidase, histidine active site |
Active_site | IPR025661 | Cysteine peptidase, asparagine active site |
Domain | IPR000668 | Peptidase C1A, papain C-terminal |
Domain | IPR014882 | Cathepsin C exclusion |
Domain | IPR039412 | Cathepsin C |
Family | IPR013128 | Peptidase C1A |
Homologous_superfamily | IPR036496 | Cathepsin C, exclusion domain superfamily |
Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
Protein | Length | Cathepsin C | Cathepsin C exclusion | Cathepsin C, exclusion domain superfamily | Cysteine peptidase, asparagine active site | Cysteine peptidase, cysteine active site | Cysteine peptidase, histidine active site | Papain-like cysteine peptidase superfamily | Peptidase C1A | Peptidase C1A, papain C-terminal |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q6P2V1
|
455 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available