Gene
plk4
- ID
- ZDB-GENE-030619-14
- Name
- polo-like kinase 4 (Drosophila)
- Symbol
- plk4 Nomenclature History
- Previous Names
-
- stk18 (1)
- wu:fi33g07
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have protein serine/threonine kinase activity. Involved in centriole assembly; cilium assembly; and developmental growth. Predicted to localize to several cellular components, including deuterosome; microtubule cytoskeleton; and nucleolus. Used to study ciliopathy. Human ortholog(s) of this gene implicated in microcephaly and chorioretinopathy 2. Is expressed in brain; eye; nervous system; and pronephros. Orthologous to human PLK4 (polo like kinase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Martin et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| microcephaly and chorioretinopathy 2 | Alliance | Microcephaly and chorioretinopathy, autosomal recessive, 2 | 616171 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| ciliopathy | AB/TU + MO2-plk4 + MO3-plk4 | standard conditions | Martin et al., 2014 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000959 | POLO box domain |
| Domain | IPR033696 | Plk4, C-terminal polo-box domain |
| Domain | IPR033698 | Plk4, second cryptic polo-box domain |
| Domain | IPR033699 | Plk4, first cryptic polo-box domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR046437 | Serine/threonine-protein kinase, first cryptic polo-box domain superfamily |
| Homologous_superfamily | IPR047108 | Plk4-like, second cryptic polo-box domain superfamily |
Domain Details Per Protein
| Protein | Length | Plk4, C-terminal polo-box domain | Plk4, first cryptic polo-box domain | Plk4-like, second cryptic polo-box domain superfamily | Plk4, second cryptic polo-box domain | POLO box domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, first cryptic polo-box domain superfamily | Tyrosine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B5U8
|
963 | ||||||||||
|
UniProtKB:Q7ZVS3
|
940 | ||||||||||
|
UniProtKB:F1RB74
|
941 |
Interactions and Pathways
No data available
Plasmids
No data available