Gene
celsr1a
- ID
- ZDB-GENE-030616-78
- Name
- cadherin EGF LAG seven-pass G-type receptor 1a
- Symbol
- celsr1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to have G protein-coupled receptor activity and calcium ion binding activity. Involved in cell migration involved in gastrulation. Predicted to localize to integral component of membrane and plasma membrane. Is expressed in several structures, including axis; germ ring; heart; optic primordium; and pleuroperitoneal region. Orthologous to human CELSR1 (cadherin EGF LAG seven-pass G-type receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- 8 figures from Li et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Lymphatic malformation 9 | 619319 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR000203 | GPS motif |
| Conserved_site | IPR020894 | Cadherin conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001791 | Laminin G domain |
| Domain | IPR001879 | GPCR, family 2, extracellular hormone receptor domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR002049 | Laminin-type EGF domain |
| Domain | IPR002126 | Cadherin-like |
| Domain | IPR017981 | GPCR, family 2-like, 7TM |
| Domain | IPR032471 | GAIN domain, N-terminal |
| Family | IPR000832 | GPCR, family 2, secretin-like |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR015919 | Cadherin-like superfamily |
| Homologous_superfamily | IPR036445 | GPCR family 2, extracellular hormone receptor domain superfamily |
| Homologous_superfamily | IPR046338 | GAIN domain superfamily |
Domain Details Per Protein
| Protein | Length | Cadherin conserved site | Cadherin-like | Cadherin-like superfamily | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like calcium-binding domain | EGF-like domain | GAIN domain, N-terminal | GAIN domain superfamily | GPCR, family 2, extracellular hormone receptor domain | GPCR family 2, extracellular hormone receptor domain superfamily | GPCR, family 2-like, 7TM | GPCR, family 2, secretin-like | GPS motif | Laminin G domain | Laminin-type EGF domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3B933
|
3031 | |||||||||||||||
|
UniProtKB:F1R9W4
|
3044 | |||||||||||||||
|
UniProtKB:A0A8M3ARK0
|
3045 | |||||||||||||||
|
UniProtKB:A0A8M3ARU0
|
3018 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
celsr1a-201
(1)
|
Ensembl | 11,760 nt | ||
| mRNA |
celsr1a-202
(1)
|
Ensembl | 9,089 nt | ||
| mRNA |
celsr1a-203
(1)
|
Ensembl | 11,679 nt |
Interactions and Pathways
No data available
Plasmids
No data available