Gene
echs1
- ID
- ZDB-GENE-030616-617
- Name
- enoyl CoA hydratase, short chain, 1, mitochondrial
- Symbol
- echs1 Nomenclature History
- Previous Names
-
- fj55e05
- si:zc217g15.1
- wu:fj55e05
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable enoyl-CoA hydratase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be active in mitochondrion. Is expressed in EVL; cardiac ventricle; digestive system; and yolk syncytial layer. Orthologous to human ECHS1 (enoyl-CoA hydratase, short chain 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6903499 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa22292 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| mitochondrial short-chain enoyl-CoA hydratase 1 deficiency | Alliance | Mitochondrial short-chain enoyl-CoA hydratase 1 deficiency | 616277 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | ClpP/crotonase-like domain superfamily | Enoyl-CoA hydratase, C-terminal | Enoyl-CoA hydratase/isomerase | Enoyl-CoA hydratase/isomerase, conserved site |
|---|---|---|---|---|---|
|
UniProtKB:Q7ZZ04
|
291 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-217G15 | ZFIN Curated Data | |
| Encodes | EST | fj55e05 | ||
| Encodes | EST | IMAGE:6903499 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001004529 (1) | 1421 nt | ||
| Genomic | GenBank:AL831745 (1) | 113703 nt | ||
| Polypeptide | UniProtKB:Q7ZZ04 (1) | 291 aa |
- Shihana, F., Cholan, P.M., Fraser, S., Oehlers, S.H., Seth, D. (2023) Investigating the role of lipid genes in liver disease using fatty liver models of alcohol and high fat in zebrafish (Danio rerio). Liver international : official journal of the International Association for the Study of the Liver. 43(11):2455-2468
- Lai, C.Y., Yeh, K.Y., Lin, C.Y., Hsieh, Y.W., Lai, H.H., Chen, J.R., Hsu, C.C., Her, G.M. (2021) MicroRNA-21 Plays Multiple Oncometabolic Roles in the Process of NAFLD-Related Hepatocellular Carcinoma via PI3K/AKT, TGF-β, and STAT3 Signaling. Cancers. 13(5):
- Takashima, S., Takemoto, S., Toyoshi, K., Ohba, A., Shimozawa, N. (2021) Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Molecular genetics and metabolism. 133(3):307-323
- Blanco, A.M., Bertucci, J.I., Hatef, A., Unniappan, S. (2020) Feeding and food availability modulate brain-derived neurotrophic factor, an orexigen with metabolic roles in zebrafish. Scientific Reports. 10:10727
- Blanco, A.M., Bertucci, J.I., Unniappan, S. (2020) FGF21 Mimics a Fasting-Induced Metabolic State and Increases Appetite in Zebrafish. Scientific Reports. 10:6993
- Fukuda, R., Marín-Juez, R., El-Sammak, H., Beisaw, A., Ramadass, R., Kuenne, C., Guenther, S., Konzer, A., Bhagwat, A.M., Graumann, J., Stainier, D.Y. (2020) Stimulation of glycolysis promotes cardiomyocyte proliferation after injury in adult zebrafish. EMBO reports. 21(8):e49752
- Zhao, Y., Bao, Z., Wan, Z., Fu, Z., Jin, Y. (2019) Polystyrene microplastic exposure disturbs hepatic glycolipid metabolism at the physiological, biochemical, and transcriptomic levels in adult zebrafish. The Science of the total environment. 710:136279
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Lin, H., Zhou, Z., Zhong, W., Huang, P., Ma, N., Zhang, Y., Zhou, C., Lai, Y., Huang, S., An, H., Sun, X., Gao, L., Lv, Z. (2017) Naringenin inhibits alcoholic injury by improving lipid metabolism and reducing apoptosis in zebrafish larvae. Oncology reports. 38(5):2877-2884
- Zhou, S., Zhao, H., Thongda, W., Zhang, D., Su, B., Yu, D., Peatman, E., Li, C. (2016) Galectins in channel catfish, Ictalurus punctatus: Characterization and expression profiling in mucosal tissues. Fish & shellfish immunology. 49:324-35
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