Gene

auts2a

ID

ZDB-GENE-030616-571

Name

activator of transcription and developmental regulator AUTS2 a

Symbol

auts2a Nomenclature History

Previous Names

auts2
si:ch211-103d22.3
si:zc103d22.3
wu:fj83b10

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Involved in embryonic viscerocranium morphogenesis; forebrain neuron development; and neuron cellular homeostasis. Used to study microcephaly and syndromic intellectual disability. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 26. Is expressed in several structures, including anterior neural keel; anterior neural rod; brain; hindbrain neural keel; and posterior neural rod. Orthologous to human AUTS2 (activator of transcription and developmental regulator AUTS2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 12 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With auts2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant intellectual developmental disorder 26	Alliance	Intellectual developmental disorder, autosomal dominant 26	615834

Associated With auts2a Via Experimental Models

Human Disease	Fish	Conditions	Citations
microcephaly	WT + MO3-auts2a	standard conditions	Beunders et al., 2013
microcephaly	WT + MO4-auts2a	standard conditions	Beunders et al., 2013
syndromic intellectual disability	WT + MO3-auts2a	standard conditions	Beunders et al., 2013
syndromic intellectual disability	WT + MO4-auts2a	standard conditions	Beunders et al., 2013

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR023246	Autism susceptibility gene 2 protein

Domain Details Per Protein

Protein	Length	Autism susceptibility gene 2 protein
UniProtKB:A0A8M9QL45 InterPro	1276
UniProtKB:E7F4D0 InterPro	1278
UniProtKB:A0A8M9PS82 InterPro	1104
UniProtKB:F1QRM5 InterPro	1126
UniProtKB:A0A2R8RIS2 InterPro	810
UniProtKB:A0A8M6Z8W2 InterPro	1271
UniProtKB:A0A1X9RK91 InterPro	811
UniProtKB:A0A1X9RK86 InterPro	1277
UniProtKB:A0A8M6Z317 InterPro	1277
UniProtKB:A0A1X9RK87 InterPro	1277
UniProtKB:A0A8M3AWT8 InterPro	1128

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	auts2a-201 (1) Ensembl	Ensembl	4,086 nt	Select Tool ZFIN BLAST
mRNA	auts2a-202 (1) Ensembl	Ensembl	4,714 nt	Select Tool ZFIN BLAST
mRNA	auts2a-203 (1) Ensembl	Ensembl	4,214 nt	Select Tool
mRNA	auts2a-204 (1) Ensembl	Ensembl	3,533 nt	Select Tool ZFIN BLAST
mRNA	auts2a-205 (1) Ensembl	Ensembl	4,122 nt	Select Tool ZFIN BLAST
mRNA	auts2a-206 (1) Ensembl	Ensembl	3,039 nt	Select Tool ZFIN BLAST
mRNA	auts2a-207 (1) Ensembl	Ensembl	5,319 nt	Select Tool ZFIN BLAST
mRNA	auts2a-208 (1) Ensembl	Ensembl	4,711 nt	Select Tool ZFIN BLAST
mRNA	auts2a-209 (1) Ensembl	Ensembl	4,843 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations