Gene
tbp
- ID
- ZDB-GENE-030616-563
- Name
- TATA box binding protein
- Symbol
- tbp Nomenclature History
- Previous Names
-
- fd20h06
- si:zc101n13.2
- wu:fd20h06
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Exhibits DNA binding activity. Involved in gastrulation; mRNA catabolic process; and transcription by RNA polymerase II. Predicted to localize to transcription factor TFIID complex and transcription factor TFIIIB complex. Human ortholog(s) of this gene implicated in late onset Parkinson's disease; schizophrenia; spinocerebellar ataxia type 17; and type 1 diabetes mellitus. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Orthologous to human TBP (TATA-box binding protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66213 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| late onset Parkinson's disease | Alliance | {Parkinson disease, susceptibility to} | 168600 |
| spinocerebellar ataxia type 17 | Alliance | Spinocerebellar ataxia 17 | 607136 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | TATA-box binding protein | TATA-box binding protein, conserved site | TATA-box binding protein, eukaryotic | TBP domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:Q7SXL3
|
302 |
Interactions and Pathways
No data available
Plasmids
No data available