Gene

pde6a

ID

ZDB-GENE-030616-42

Name

phosphodiesterase 6A, cGMP-specific, rod, alpha

Symbol

pde6a Nomenclature History

Previous Names

si:bz1d10.3
si:rp71-1d10.3

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in G protein-coupled receptor signaling pathway; regulation of cytosolic calcium ion concentration; and retina development in camera-type eye. Human ortholog(s) of this gene implicated in retinitis pigmentosa 43. Is expressed in retina; retinal neural layer; and retinal photoreceptor layer. Orthologous to human PDE6A (phosphodiesterase 6A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from Crouzier et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pde6a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
retinitis pigmentosa 43	Alliance	Retinitis pigmentosa 43	613810

Associated With pde6a Via Experimental Models

Human Disease	Fish	Conditions	Citations
retinitis pigmentosa	pde6a^{sa14581/sa14581} (AB)	standard conditions	Crouzier et al., 2021

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023174	3'5'-cyclic nucleotide phosphodiesterase, conserved site
Domain	IPR002073	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Domain	IPR003018	GAF domain
Domain	IPR003607	HD/PDEase domain
Family	IPR023088	3'5'-cyclic nucleotide phosphodiesterase
Homologous_superfamily	IPR029016	GAF-like domain superfamily
Homologous_superfamily	IPR036971	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily

Domain Details Per Protein

Protein	Length	3'5'-cyclic nucleotide phosphodiesterase	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily	3'5'-cyclic nucleotide phosphodiesterase, conserved site	GAF domain	GAF-like domain superfamily	HD/PDEase domain
UniProtKB:Q800E7 InterPro	858

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	pde6a-201 (1) Ensembl	Ensembl	3,033 nt	Select Tool
mRNA	pde6a-203 (1) Ensembl	Ensembl	3,467 nt	Select Tool ZFIN BLAST
ncRNA	pde6a-002 (1) Ensembl	Ensembl	733 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations