Gene
pde6a
- ID
- ZDB-GENE-030616-42
- Name
- phosphodiesterase 6A, cGMP-specific, rod, alpha
- Symbol
- pde6a Nomenclature History
- Previous Names
-
- si:bz1d10.3
- si:rp71-1d10.3
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to have 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in G protein-coupled receptor signaling pathway; regulation of cytosolic calcium ion concentration; and retina development in camera-type eye. Human ortholog(s) of this gene implicated in retinitis pigmentosa 43. Is expressed in retina; retinal neural layer; and retinal photoreceptor layer. Orthologous to human PDE6A (phosphodiesterase 6A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Crouzier et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| retinitis pigmentosa 43 | Alliance | Retinitis pigmentosa 43 | 613810 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| retinitis pigmentosa | pde6asa14581/sa14581 (AB) | standard conditions | Crouzier et al., 2021 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023174 | 3'5'-cyclic nucleotide phosphodiesterase, conserved site |
| Domain | IPR002073 | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain |
| Domain | IPR003018 | GAF domain |
| Domain | IPR003607 | HD/PDEase domain |
| Family | IPR023088 | 3'5'-cyclic nucleotide phosphodiesterase |
| Homologous_superfamily | IPR029016 | GAF-like domain superfamily |
| Homologous_superfamily | IPR036971 | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily |
Domain Details Per Protein
| Protein | Length | 3'5'-cyclic nucleotide phosphodiesterase | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily | 3'5'-cyclic nucleotide phosphodiesterase, conserved site | GAF domain | GAF-like domain superfamily | HD/PDEase domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q800E7
|
858 |
Interactions and Pathways
No data available
Plasmids
No data available