Gene
stat4
- ID
- ZDB-GENE-030616-264
- Name
- signal transducer and activator of transcription 4
- Symbol
- stat4 Nomenclature History
- Previous Names
-
- si:by134g18.2
- si:by51f19.1
- si:dz182h3.3
- si:dz199m19.1
- si:dz73o4.2
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in vasculogenesis. Predicted to localize to cytosol and nucleus. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; IgA glomerulonephritis; Sjogren's syndrome; genital herpes; and rheumatic disease (multiple). Is expressed in anterior lateral plate mesoderm and pharyngeal arch. Orthologous to human STAT4 (signal transducer and activator of transcription 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Meng et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000980 | SH2 domain |
| Domain | IPR013799 | STAT transcription factor, protein interaction |
| Domain | IPR013800 | STAT transcription factor, all-alpha domain |
| Domain | IPR013801 | STAT transcription factor, DNA-binding |
| Domain | IPR046991 | Signal transducer and activator of transcription 4 , coiled-coil domain |
| Domain | IPR048988 | Signal transducer and activator of transcription, linker domain |
| Family | IPR001217 | Transcription factor STAT |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR012345 | STAT transcription factor, DNA-binding, N-terminal |
| Homologous_superfamily | IPR015988 | STAT transcription factor, coiled coil |
| Homologous_superfamily | IPR036535 | STAT transcription factor, N-terminal domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Length | p53-like transcription factor, DNA-binding domain superfamily | SH2 domain | SH2 domain superfamily | Signal transducer and activator of transcription 4 , coiled-coil domain | Signal transducer and activator of transcription, linker domain | STAT transcription factor, all-alpha domain | STAT transcription factor, coiled coil | STAT transcription factor, DNA-binding | STAT transcription factor, DNA-binding, N-terminal | STAT transcription factor, N-terminal domain superfamily | STAT transcription factor, protein interaction | Transcription factor STAT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q8AW20
|
667 | ||||||||||||
|
UniProtKB:A0A8M2BFB6
|
732 | ||||||||||||
|
UniProtKB:A0A8M9QAM0
|
694 | ||||||||||||
|
UniProtKB:B0S790
|
731 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA | ottdart00000001760 (1) | Havana | 531 nt | ||
| mRNA | ottdart00000001847 (1) | Havana | 1,655 nt | ||
| mRNA | ottdart00000004046 (1) | Havana | 2,245 nt | ||
| mRNA |
stat4-201
(1)
|
Ensembl | 2,295 nt | ||
| mRNA |
stat4-202
(1)
|
Ensembl | 2,907 nt | ||
| mRNA |
stat4-203
(1)
|
Ensembl | 6,258 nt | ||
| mRNA |
stat4-204
(1)
|
Ensembl | 4,749 nt |
Interactions and Pathways
No data available
Plasmids
No data available