Gene

hectd1

ID

ZDB-GENE-030616-153

Name

HECT domain containing 1

Symbol

hectd1 Nomenclature History

Previous Names

si:dz142b24.4
wu:fc30d02 (1)
wu:fc49f09 (1)
wu:fd99d04 (1)
zgc:123053
zgc:92832

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in anatomical structure development; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein K63-linked ubiquitination. Predicted to act upstream of or within protein ubiquitination. Predicted to be active in nuclear speck. Orthologous to human HECTD1 (HECT domain E3 ubiquitin protein ligase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hectd1 Human Ortholog

No data available

Associated With hectd1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000569	HECT domain
Domain	IPR010606	Mib-herc2
Domain	IPR012919	SUN domain
Domain	IPR041200	FKBP3, basic tilted helix bundle domain
Family	IPR045322	E3 ubiquitin-protein ligase HECTD1/TRIP12-like
Homologous_superfamily	IPR008979	Galactose-binding-like domain superfamily
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR035983	HECT, E3 ligase catalytic domain
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Homologous_superfamily	IPR037252	Mib/herc2 domain superfamily
Repeat	IPR002110	Ankyrin repeat

Domain Details Per Protein

Protein	Length	Ankyrin repeat	Ankyrin repeat-containing domain superfamily	Armadillo-like helical	Armadillo-type fold	E3 ubiquitin-protein ligase HECTD1/TRIP12-like	FKBP3, basic tilted helix bundle domain	Galactose-binding-like domain superfamily	HECT domain	HECT, E3 ligase catalytic domain	Mib-herc2	Mib/herc2 domain superfamily	SUN domain
UniProtKB:A0A8M3AJX0 InterPro	2585
UniProtKB:A0A8M3AUD5 InterPro	2523
UniProtKB:A0A0R4IGL6 InterPro	2509
UniProtKB:Q8JFV5 InterPro	2576
UniProtKB:A0A8M3AJX5 InterPro	1334
UniProtKB:A0A8M3AJ23 InterPro	2524
UniProtKB:A0A8M3ARF8 InterPro	2538
UniProtKB:A0A2R8PW57 InterPro	2570

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	hectd1-201 (1) Ensembl	Ensembl	9,030 nt	Select Tool ZFIN BLAST
mRNA	hectd1-205 (1) Ensembl	Ensembl	745 nt	Select Tool ZFIN BLAST
mRNA	hectd1-206 (1) Ensembl	Ensembl	566 nt	Select Tool ZFIN BLAST
mRNA	hectd1-208 (1) Ensembl	Ensembl	8,669 nt	Select Tool ZFIN BLAST
mRNA	hectd1-209 (1) Ensembl	Ensembl	7,971 nt	Select Tool ZFIN BLAST
mRNA	hectd1-210 (1) Ensembl	Ensembl	8,154 nt	Select Tool ZFIN BLAST
ncRNA	hectd1-002 (1) Ensembl	Ensembl	1,761 nt	Select Tool ZFIN BLAST
ncRNA	hectd1-003 (1) Ensembl	Ensembl	1,221 nt	Select Tool ZFIN BLAST
ncRNA	hectd1-004 (1) Ensembl	Ensembl	731 nt	Select Tool ZFIN BLAST
ncRNA	hectd1-007 (1) Ensembl	Ensembl	587 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations