Gene

cacna2d3

ID

ZDB-GENE-030616-133

Name

calcium channel, voltage dependent, alpha2/delta subunit 3

Symbol

cacna2d3 Nomenclature History

Previous Names

dory
si:busm1-136d19.1
si:dz136d19.1

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to enable voltage-gated calcium channel activity. Predicted to act upstream of or within calcium ion transmembrane transport and regulation of monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of voltage-gated calcium channel complex. Orthologous to human CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Hu et al., 2024

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cacna2d3 Human Ortholog

No data available

Associated With cacna2d3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002035	von Willebrand factor, type A
Domain	IPR013608	VWA N-terminal
Domain	IPR013680	Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region
Family	IPR051173	Voltage-dependent calcium channel subunit alpha-2/delta
Homologous_superfamily	IPR036465	von Willebrand factor A-like domain superfamily

Domain Details Per Protein

Protein	Length	Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region	Voltage-dependent calcium channel subunit alpha-2/delta	von Willebrand factor A-like domain superfamily	von Willebrand factor, type A	VWA N-terminal
UniProtKB:F1R3X8 InterPro	1082
UniProtKB:A0A8M6Z1U2 InterPro	1083
UniProtKB:A0A8M2BK51 InterPro	1076
UniProtKB:A0A8M2BK91 InterPro	1077

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cacna2d3-001 (1)	Havana	422 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	cacna2d3-201 (1) Ensembl	Ensembl	4,324 nt	Select Tool ZFIN BLAST
mRNA	cacna2d3-202 (1) Ensembl	Ensembl	3,069 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations