Gene
patj
- ID
- ZDB-GENE-030616-129
- Name
- PATJ crumbs cell polarity complex component
- Symbol
- patj Nomenclature History
- Previous Names
-
- inadl (1)
- mpdz
- mupp1
- si:busm1-129i22.4
- si:dz129i22.4
- wu:fc76h08
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to be involved in microtubule organizing center organization; regulation of microtubule cytoskeleton organization; and tight junction assembly. Predicted to be active in several cellular components, including apical part of cell; bicellular tight junction; and plasma membrane. Orthologous to human PATJ (PATJ crumbs cell polarity complex component).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa648 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa5970 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa6702 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24135 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa24136 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24137 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32397 | Allele with one point mutation | Unknown | Missense, Splice Site | ENU | |
| sa37482 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43804 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa43805 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 10 of 10
Show
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | L27-2 | L27 domain | L27 domain superfamily | PDZ domain | PDZ domain-containing scaffold protein | PDZ superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B8K6
|
1914 | ||||||
|
UniProtKB:A0A8M3AMY8
|
1885 | ||||||
|
UniProtKB:A0A8M3B5G9
|
1894 | ||||||
|
UniProtKB:Q1LXN3
|
1831 |
1 - 4 of 4
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-112F11 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-38N4 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-129I22 | ZFIN Curated Data | |
| Encodes | EST | fc76h08 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001127185 (1) | 5496 nt | ||
| Genomic | GenBank:AL929239 (2) | 155623 nt | ||
| Polypeptide | UniProtKB:A0A8M2B8K6 (1) | 1914 aa |
- Rozman, V., Kunej, T. (2018) Harnessing Omics Big Data in Nine Vertebrate Species by Genome-Wide Prioritization of Sequence Variants with the Highest Predicted Deleterious Effect on Protein Function. Omics : a journal of integrative biology. 22(6):410-421
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Gottgens, B., Barton, L.M., Chapman, M.A., Sinclair, A.M., Knudsen, B., Grafham, D., Gilbert, J.G., Rogers, J., Bentley, D.R., and Green, A.R. (2002) Transcriptional regulation of the stem cell leukemia gene (SCL) - comparative analysis of five vertebrate SCL loci. Genome research. 12(5):749-759
1 - 4 of 4
Show