Gene
nrp1a
- ID
- ZDB-GENE-030519-2
- Name
- neuropilin 1a
- Symbol
- nrp1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Enables vascular endothelial growth factor receptor activity. Involved in several processes, including positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of filopodium assembly; and vascular endothelial growth factor receptor signaling pathway. Acts upstream of or within with a positive effect on angiogenesis involved in wound healing and cell activation. Acts upstream of or within several processes, including axon development; circulatory system development; and regulation of retinal ganglion cell axon guidance. Predicted to be located in membrane. Predicted to be active in axon; focal adhesion; and plasma membrane. Is expressed in several structures, including cardiovascular system; cranial neural crest cell; hematopoietic stem cell; hypochord; and nervous system. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human NRP1 (neuropilin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 39 figures from 31 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 12 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hu9963 | Allele with one deletion | Unknown | Frameshift, Premature Stop | TALEN | |
| hu10012 | Allele with one deletion | Unknown | Frameshift, Premature Stop | TALEN | |
| la028593Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa32 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa33 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa34 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa1485 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24429 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24430 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37806 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Coagulation factor 5/8, C-terminal domain | Concanavalin A-like lectin/glucanase domain superfamily | CUB domain | Galactose-binding-like domain superfamily | MAM domain | Neuropilin | Neuropilin, C-terminal | Neuropilin/Multicopper Oxidase/Coagulation Factor | Spermadhesin, CUB domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IFP8
|
926 | |||||||||
|
UniProtKB:Q8QFX6
|
923 | |||||||||
|
UniProtKB:Q69DB8
|
923 | |||||||||
|
UniProtKB:A0A8M3AYV8
|
919 | |||||||||
|
UniProtKB:Q1RLY9
|
916 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-134F24 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-97G1 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-9D12 | ZFIN Curated Data | |
| Contained in | BAC | RP71-26B20 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:111785 | ||
| Encodes | cDNA | MGC:136674 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195315 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001040326 (1) | 3901 nt | ||
| Genomic | GenBank:BX323074 (1) | 153860 nt | ||
| Polypeptide | UniProtKB:A0A0R4IFP8 (1) | 926 aa |
- Liu, Z.Z., Liu, L.Y., Zhu, L.Y., Zhu, J., Luo, J.Y., Wang, Y.F., Xu, H.A. (2024) Plexin B3 guides axons to cross the midline in vivo. Frontiers in Cellular Neuroscience. 18:12929691292969
- Singh Angom, R., Wang, Y., Wang, E., Dutta, S., Mukhopadhyay, D. (2023) Conditional, Tissue-Specific CRISPR/Cas9 Vector System in Zebrafish Reveals the Role of Nrp1b in Heart Regeneration. Arteriosclerosis, Thrombosis, and Vascular Biology. 43(10):1921-1934
- Capon, S.J., Uribe, V., Dominado, N., Ehrlich, O., Smith, K.A. (2022) Endocardial identity is established during early somitogenesis by Bmp signalling acting upstream of npas4l and etv2. Development (Cambridge, England). 149(9):
- Guo, Y., Oliveros, C.F., Ohshima, T. (2022) CRMP2 and CRMP4 are required for the formation of commissural tracts in the developing zebrafish forebrain. Developmental Neurobiology. 82(6):533-544
- Hui, S.P., Sugimoto, K., Sheng, D.Z., Kikuchi, K. (2022) Regulatory T cells regulate blastemal proliferation during zebrafish caudal fin regeneration. Frontiers in immunology. 13:981000
- Wang, G.T., Pan, H.Y., Lang, W.H., Yu, Y.D., Hsieh, C.H., Kuan, Y.S. (2021) Three-dimensional multi-gene expression maps reveal cell fate changes associated with laterality reversal of zebrafish habenula. Journal of neuroscience research. 99(6):1632-1645
- Klems, A., van Rijssel, J., Ramms, A.S., Wild, R., Hammer, J., Merkel, M., Derenbach, L., Préau, L., Hinkel, R., Suarez-Martinez, I., Schulte-Merker, S., Vidal, R., Sauer, S., Kivelä, R., Alitalo, K., Kupatt, C., van Buul, J.D., le Noble, F. (2020) The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models. Nature communications. 11:5319
- Li, G.X., Zhang, S., Liu, R., Singh, B., Singh, S., Quinn, D.I., Crump, G., Gill, P.S. (2020) Tetraspanin18 regulates angiogenesis through VEGFR2 and Notch pathways. Biology Open. 10(2):
- Wang, Y., Zhang, D., Zhou, F., Zhou, M., Li, Q., Chen, J., Yang, J. (2020) Whole-Mount In Situ Hybridization in Zebrafish Embryos and Tube Formation Assay in iPSC-ECs to Study the Role of Endoglin in Vascular Development. Journal of visualized experiments : JoVE. (159):
- Weinberger, M., Simões, F.C., Patient, R., Sauka-Spengler, T., Riley, P.R. (2020) Functional Heterogeneity within the Developing Zebrafish Epicardium. Developmental Cell. 52(5):574-590.e6
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