Gene
gnrh2
- ID
- ZDB-GENE-030516-1
- Name
- gonadotropin-releasing hormone 2
- Symbol
- gnrh2 Nomenclature History
- Previous Names
-
- GnRH-II
- cGnRH-II (1)
- cII gonadotropin releasing hormone
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable gonadotropin-releasing hormone receptor binding activity. Acts upstream of or within brain development; camera-type eye development; and regulation of feeding behavior. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; female organism; gonad; male organism; and musculature system. Orthologous to human GNRH2 (gonadotropin releasing hormone 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 39 figures from 23 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Marvel et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| zf3139 | Allele with one delins | Unknown | Frameshift | TALEN |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-gnrh2 | N/A | Wu et al., 2006 |
| MO2-gnrh2 | N/A | Wu et al., 2006 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Gonadoliberin | Gonadotropin-releasing hormone |
|---|---|---|---|
|
UniProtKB:Q5Y835
|
86 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(gnrh2:EGFP) |
|
| 1 | (4) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-87D8 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194380 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194386 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_181439 (1) | 659 nt | ||
| Genomic | GenBank:BX530059 (1) | 179045 nt | ||
| Polypeptide | UniProtKB:Q5Y835 (1) | 86 aa |
- Li, Y., Li, X., Ye, D., Zhang, R., Liu, C., He, M., Wang, H., Hu, W., Sun, Y. (2024) Endogenous biosynthesis of docosahexaenoic acid (DHA) regulates fish oocyte maturation by promoting pregnenolone production. Zoological research. 45:176188176-188
- Wang, M., Luo, J., Dai, L., Feng, M., Cao, X., Zhang, J., Wan, Y., Yang, X., Wang, Y. (2024) Foxp2 deficiency impairs reproduction by modulating the hypothalamic-pituitary-gonadal axis in zebrafish. Biology of reproduction. 110(5):908-923
- Zhang, F., Tang, C., Wang, J., Lin, T., Ge, W., He, C., Yang, C., Zuo, Z. (2024) Letrozole induced a polycystic ovary syndrome model in zebrafish by interfering with the hypothalamic-pituitary-gonadal axis. Environmental pollution (Barking, Essex : 1987). 347:123723
- Guo, J., Huang, W., Zhao, X., Ji, N., Chen, K., Shi, Y., Feng, J., Zou, J., Wang, J. (2023) The expanded ISG12 family in zebrafish: ISG12.1 suppresses virus replication via targeting viral phosphoprotein. Developmental and comparative immunology. 142:104672
- Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201
- Duan, M., Guo, X., Chen, X., Guo, M., Xu, H., Hao, L., Wang, C., Yang, Y. (2022) Life Cycle Exposure to Cyhalofop-Butyl Induced Reproductive Toxicity in Zebrafish. Toxics. 10(9)
- Gonçalves, C., Kareklas, K., Teles, M.C., Varela, S.A.M., Costa, J., Leite, R.B., Paixão, T., Oliveira, R.F. (2022) Phenotypic architecture of sociality and its associated genetic polymorphisms in zebrafish. Genes, brain, and behavior. 21(5):e12809
- Rodrigues, M.S., Tovo-Neto, A., Rosa, I.F., Doretto, L.B., Fallah, H.P., Habibi, H.R., Nóbrega, R.H. (2022) Thyroid Hormones Deficiency Impairs Male Germ Cell Development: A Cross Talk Between Hypothalamic-Pituitary-Thyroid, and-Gonadal Axes in Zebrafish. Frontiers in cell and developmental biology. 10:865948
- Tsakoumis, E., Ahi, E.P., Schmitz, M. (2022) Impaired leptin signaling causes subfertility in female zebrafish. Molecular and Cellular Endocrinology. 546:111595
- Li, Y., Zhao, T., Liu, Y., Lin, H., Li, S., Zhang, Y. (2021) Knockout of tac3 Genes in Zebrafish Shows No Impairment of Reproduction. General and comparative endocrinology. 311:113839
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